Eosinophils in Colorectal Cancer: Emerging Insights into Anti-Tumoral Mechanisms and Clinical Implications
Metadatos
Mostrar el registro completo del ítemAutor
López Pérez, David; Prados Lopez, Belen; Gálvez Peralta, Julio Juan; León, Josefa; Carazo, ÁngelEditorial
MDPI
Materia
eosinophils; colorectal cancer tumor microenvironment
Fecha
2024-06-01Referencia bibliográfica
López Pérez, D. et. al. Int. J. Mol. Sci. 2024, 25, 6098. [https://doi.org/10.3390/ijms25116098]
Patrocinador
Instituto de Salud Carlos III, grant number DTS22/00151.; (“Programa de doctorado en Bioquímica y Biología Molecular”, B16.56.1); (“Formación de Profesorado Universitario” grant FPU18/04432).Resumen
Eosinophils are myeloid effector cells whose main homing is the gastrointestinal tract.
There, they take part in type I and type II immune responses. They also contribute to other nonimmunological
homeostatic functions like mucus production, tissue regeneration, and angiogenesis.
In colorectal cancer (CRC), eosinophils locate in the center of the tumor and in the front of invasion
and play an anti-tumoral role. They directly kill tumor cells by releasing cytotoxic compounds
and eosinophil extracellular traps or indirectly by activating other immune cells via cytokines. As
CRC progresses, the number of infiltrating eosinophils decreases. Although this phenomenon
is not fully understood, it is known that some changes in the microenvironmental milieu and
microbiome can affect eosinophil infiltration. Importantly, a high number of intratumoral eosinophils
is a favorable prognostic factor independent from the tumor stage. Moreover, after immunotherapy,
responding patients usually display eosinophilia, so eosinophils could be a good biomarker candidate
to monitor treatment outcomes. Finally, even though eosinophils seem to play an interesting antitumoral
role in CRC, much more research is needed to fully understand their interactions in the
CRC microenvironment. This review explores the multifaceted roles of eosinophils in colorectal
cancer, highlighting their anti-tumoral effects, prognostic significance, and potential as a biomarker
for treatment outcomes.