Fear in action: Fear conditioning and alleviation through body movements
Metadatos
Mostrar el registro completo del ítemAutor
Alemany González, Maria; Wokke, Martijn E.; Chiba, Toshinori; Narumi, Takuji; Kaneko, Naotsugu; Yokoyama, Hikaru; Watanabe, Katsumi; Nakazawa, Kimitaka; Imamizu, Hiroshi; Koizumi, AiEditorial
Elsevier
Fecha
2024-02-06Referencia bibliográfica
Alemany-González, M., et al. Fear in action: Fear conditioning and alleviation through body movements. iScience 27 (2024), 109099 [10.1016/j.isci.2024.109099]
Patrocinador
Japan Science and Technology Agency (JST) Moonshot (20343198, JPMJMS2012); Japan Society for the Promotion of Science (JSPS), Transformative Research Area (A); Japan Science and Technology Agency (JST) (Presto (18068712); Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research (B) (18H02714 and 22H01111); Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research (A) (22H00090)Resumen
Fear memories enhance survival especially when the memories guide defensive movements to minimize
harm. Accordingly, fear memories and body movements have tight relationships in animals: Fear memory
acquisition results in adapting reactive defense movements, while training active defense movements
reduces fear memory. However, evidence in humans is scarce because their movements are typically suppressed
in experiments. Here, we tracked adult participants’ body motions while they underwent ecologically
valid fear conditioning in a 3D virtual space. First, with body motion tracking, we revealed that
distinct spatiotemporal body movement patterns emerge through fear conditioning. Second, subsequent
training to actively avoid threats with naturalistic defensive actions led to a long-term (24 h) reduction of
physiological and embodied conditioned responses, while extinction or vicarious training only transiently
reduced the responses. Together, our results highlight the role of body movements in human fear memory
and its intervention.