The molecular basis of cell memory in mammals: The epigenetic cycle
Metadatos
Mostrar el registro completo del ítemEditorial
American Association for the Advancement of Science (AAAS)
Fecha
2024-02-28Referencia bibliográfica
Mencía Espinosa-Martínez et al., The molecular basis of cell memory in mammals: The epigenetic cycle. Sci. Adv. 10, eadl3188 (2024). DOI: 10.1126/sciadv.adl3188
Patrocinador
Grant (EUR2021-122005) funded by MCIN/AEI/10.13039/501100011033; Spanish Ministry of Science and Innovation (PID2022-137060NB-I00 and PID2019-108108-100); Instituto de Salud Carlos III (IHRC22/00007); Andalusian regional government (PC-0246-2017, PIER-0211-2019, and PY20_00681); University of Granada (A-BIO-6-UGR20)Resumen
Cell memory refers to the capacity of cells to maintain their gene expression program once the initiating
environmental signal has ceased. This exceptional feature is key during the formation of mammalian organisms,
and it is believed to be in part mediated by epigenetic factors that can endorse cells with the landmarks required
to maintain transcriptional programs upon cell duplication. Here, we review current literature analyzing the
molecular basis of epigenetic memory in mammals, with a focus on the mechanisms by which transcriptionally
repressive chromatin modifications such as methylation of DNA and histone H3 are propagated through mitotic
cell divisions. The emerging picture suggests that cellular memory is supported by an epigenetic cycle in which
reversible activities carried out by epigenetic regulators in coordination with cell cycle transition create a multiphasic
system that can accommodate both maintenance of cell identity and cell differentiation in proliferating
stem cell populations.