A Synthetic Model of the Mucosa for Oral Penetration Studies
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Alonso, Cristina; Martí, Meritxell; Ramos, Anderson; Calpena, Ana Cristina; Clares Naveros, Beatriz; Coderch, LuisaEditorial
MDPI
Materia
Synthetic membrane Mucosa membrane Waterproofing formulations
Date
2023-12-12Referencia bibliográfica
Alonso, C.; Martí, M.; Ramos, A.; Calpena, A.C.; Clares-Naveros, B.; Coderch, L. A Synthetic Model of the Mucosa for Oral Penetration Studies. Membranes 2023, 13, 905. https://doi.org/10.3390/membranes13120905
Sponsorship
Consejo Superior de Investigaciones Científicas “Modificación de la mucosa como protección frente al SARS-CoV-2” (CSIC-COV19-130)Abstract
The main objective of this study is the evaluation of the use of a synthetic membrane,
Nuclepore, as a model for permeation studies through sublingual mucosa. The permeability of
two types of membranes, porcine sublingual oral mucosa and a synthetic Nuclepore membrane, to
water was compared. Moreover, the water permeability of membranes modified with waterproofing
formulations was measured to study their ability to protect against the penetration of viruses, toxins,
etc. A relatively high correlation (R2 0.88) was obtained between the transmucosal water loss (TMWL)
values of the artificial membrane and the mucosa. These results support the possible use of this
synthetic membrane in the screening of the water permeability of formulations. In addition, studies
of the permeation of different actives, drugs, and biocides through the two membranes were carried
out, and these results were compared with their skin permeation data. The synthetic membrane
does not seem to discern between compounds in terms of permeability. However, the permeation of
caffeine through intact or modified membranes incorporating waterproofing formulations presents
similar permeation profiles through the synthetic membrane and mucosa. The results from these
assays should lend support to the use of this synthetic membrane when screening formulations to be
applied in oral penetration studies.