Plant-Derived Bioactive Compounds for Rhabdomyosarcoma Therapy In Vitro: A Systematic Review
Metadatos
Mostrar el registro completo del ítemAutor
Mesas Hernández, Cristina; Segura, Beatriz; Perazzoli, Gloria; Chico Lozano, María Ángeles; Moreno Pérez, Javier; Doello, Kevin; Prados Salazar, José Carlos; Melguizo Alonso, ConsolaciónEditorial
MDPI
Materia
Rhabdomyosarcoma Plant extract Bioactive compounds
Fecha
2023-12-04Referencia bibliográfica
Mesas, C.; Segura, B.; Perazzoli, G.; Chico, M.A.; Moreno, J.; Doello, K.; Prados, J.; Melguizo, C. Plant-Derived Bioactive Compounds for Rhabdomyosarcoma Therapy In Vitro: A Systematic Review. Appl. Sci. 2023, 13, 12964. https://doi.org/10.3390/app132312964
Patrocinador
Spanish Ministry of Science and Innovation (FEDER) (CPP2022-009967 and CPP2022-010017); Spanish Ministry of Universities and Science (RTC2019-006870-1)Resumen
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, constitutes
approximately 40% of all recorded soft tissue tumors and is associated with a poor prognosis, with
survival rates of less than 20% at 3 years. The development of resistance to cytotoxic drugs is a
primary contributor to therapeutic failure. Consequently, the exploration of new therapeutic strategies
is of vital importance. The potential use of plant extracts and their bioactive compounds emerges as a
complementary treatment for this type of cancer. This systematic review focuses on research related
to plant extracts or isolated bioactive compounds exhibiting antitumor activity against RMS cells.
Literature searches were conducted in PubMed, Scopus, Cochrane, and WOS. A total of 173 articles
published to date were identified, although only 40 were finally included to meet the inclusion
criteria. Furthermore, many of these compounds are readily available and have reduced cytotoxicity,
showing an apoptosis-mediated mechanism of action to induce tumor cell death. Interestingly, their
use combined with chemotherapy or loaded with nanoparticles achieves better results by reducing
toxicity and/or facilitating entry into tumor cells. Future in vivo studies will be necessary to verify
the utility of these natural compounds as a therapeutic tool for RMS.