Comparison of two chemiluminescent immunoassays in the detection of measles IgM antibodies
Metadatos
Mostrar el registro completo del ítemAutor
Gómez-Camarasa, Cristina; Lara Oya, Ana; Cobo, Fernando; Sampedro-Martínez, Antonio; Rodríguez-Granger, Javier; Gutiérrez Fernández, José; Navarro Marí, José MaríaEditorial
Elsevier
Materia
Measles Serology Chemiluminescent immunoassay
Fecha
2016-11Referencia bibliográfica
Gómez-Camarasa C, Lara-Oya A, Cobo F, Sampedro-Martínez A, Rodríguez-Granger J, Gutierrez-Fernández J, Navarro-Marí JM. Comparison of two chemiluminescent immunoassays in the detection of measles IgM antibodies. J Virol Methods. 2016 Nov;237:38-39. DOI: 10.1016/j.jviromet.2016.08.018
Resumen
Serological confirmation of measles is achieved by detecting the specific immunoglobulin M (IgM), and it is important to evaluate new commercial inmunoassays in order to ensure the quality of results. The objective of this study was to compare the performance of a novel automated chemiluminescent immunoassay (CLIA), Virclia IgM measles (Vircell, Spain), with that of the widely used Liaison measles IgM assay (DiaSorin, Italy). A panel of 86 sera from laboratory-confirmed cases was used for the sensitivity calculation, and 59 sera from healthy individuals and those with other viral infections were used for the specificity calculation. Sensitivity values were 96.5% for Virclia and 97.6% for Liaison; specificity values were 93.2% for Virclia and 96.6% for Liaison; neither difference was statistically significant VirClia IgM measles is a good alternative to other immunoassays for the serological confirmation of measles.