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dc.contributor.authorKiwitt Cárdenas, Jonathan
dc.contributor.authorArense Gonzalo, Julián J.
dc.contributor.authorAdoamnei, Evdochia
dc.contributor.authorSarabia Cos, Laura
dc.contributor.authorVela Soria, Fernando 
dc.contributor.authorFernández Cabrera, Mariana Fátima 
dc.contributor.authorGosálvez, Jaime
dc.contributor.authorMendiola, Jaime
dc.contributor.authorTorres-Cantero, Alberto M.
dc.identifier.citationScience of the Total Environment 912 (2024) 169314 [10.1016/j.scitotenv.2023.169314]es_ES
dc.description.abstractPeople are daily exposed to multiple endocrine disruptor compounds (EDCs) that may interfere with different molecular and cellular processes, promoting a potential estrogenic, androgenic, or anti-androgenic state. However, most epidemiological studies attempting to establish relationships between EDCs exposure and health effects are still considering individual compounds. A few studies have shown associations between exposure to individual non-persistent EDCs and sperm DNA fragmentation (SDF) in different male populations. Thus, the aim of this study was to investigate associations between combined exposure to non-persistent EDCs and SDF index in young men. A cross-sectional study was conducted with 158 healthy university students from Southeaster Spain. The participants provided spot urine and semen samples on the same day. The concentrations of urinary bisphenol A (BPA), benzophenones [2,4-dihydroxybenzophenone (BP-1); 2,2′,4,4′-tetrahydroxybenzophenone (BP-2), 2-hydroxy-4-methoxybenzophenone (BP-3), 2,2′-dihydroxy-4-methoxybenzophenone (BP-8), 4-hydroxybenzophenone (4OHBP)], and parabens (methylparaben, ethylparaben, propylparaben, butylparaben) were measured by dispersive liquid-liquid microextraction and ultrahigh-performance liquid chromatography with tandem mass spectrometry detection. SDF was analysed using a Sperm Chromatin Dispersion test. Statistical analyses were carried out using Bayesian Kernel Machine Regression models to evaluate associations between combined exposure to these compounds and SDF index while adjusting by relevant covariates. The increase in urinary concentration of 4OHBP was found to be the most important contributor to the negative association between urinary EDCs concentrations and SDF index, being of -5.5 % [95 % CI: -10.7, -0.3] for those in percentile 50, and -5.4 % [95 % CI: -10.8, -0.1] for those in percentile 75. No significant associations were observed between other EDCs and SDF index. Our findings show that urinary 4OHBP levels may be associated with a decrease in the SDF index. Nonetheless, the effects we observed were likely to be small and of uncertain clinical significance. Further research is needed to replicate our findings in other male populations.es_ES
dc.description.sponsorshipFundación Séneca, Agencia de Ciencia y Tecnología de la Región de Murcia [08808/PI/08, 19443/PI/14]es_ES
dc.description.sponsorshipConsejería de Innovación, Junta de Andalucía [P09-CTS-5488]es_ES
dc.description.sponsorshipMinisterio de Economía, Industria y Competitividad, Instituto de Salud Carlos III (Acción Estratégica en Salud, AES) [PI10/00985, PI13/01237, PI13/ 02406]es_ES
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.subjectBayesian Kernel Machine Regressiones_ES
dc.subjectEndocrine disruptor compoundses_ES
dc.subjectMale infertilityes_ES
dc.titleUrinary concentrations of bisphenol A, parabens and benzophenone-type ultra violet light filters in relation to sperm DNA fragmentation in young men: A chemical mixtures approaches_ES

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Atribución-NoComercial 4.0 Internacional
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