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Higher Plasma Levels of Endocannabinoids and Analogues Correlate With a Worse Cardiometabolic Profile in Young Adults
dc.contributor.author | Di, Xinyu | |
dc.contributor.author | Martínez Téllez, Borja Manuel | |
dc.contributor.author | Krekels, Elke H.J. | |
dc.contributor.author | Jurado Fasoli, Lucas | |
dc.contributor.author | Osuna Prieto, Francisco Javier | |
dc.contributor.author | Ortiz Álvarez, Lourdes | |
dc.contributor.author | Hankemeier, Thomas | |
dc.contributor.author | Rensen, Patrick C. N. | |
dc.contributor.author | Ruiz Ruiz, Jonatan | |
dc.contributor.author | Kohler, Isabelle | |
dc.date.accessioned | 2024-04-04T06:55:00Z | |
dc.date.available | 2024-04-04T06:55:00Z | |
dc.date.issued | 2023-11-15 | |
dc.identifier.citation | The Journal of Clinical Endocrinology & Metabolism, 2023, 00, 1–10 [10.1210/clinem/dgad668] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/90377 | |
dc.description.abstract | Context: The endocannabinoid system (ECS) is a signaling system composed of endocannabinoids (eCBs), their receptors, and the enzymes involved in their synthesis and metabolism. Alterations in the ECS are linked to the development of cardiometabolic diseases. Objective: Here, we investigated the relationship between plasma levels of eCBs and their analogues with body composition and cardiometabolic risk factors. Methods: The study included 133 young adults (age 22.1 ± 2.2 years, 67% women). Fasting plasma levels of eCBs and their analogues were measured using liquid chromatography-tandem mass spectrometry. Body composition, brown adipose tissue (BAT) volume, glucose uptake, and traditional cardiometabolic risk factors were measured. Results: Plasma levels of eCBs and several eCB analogues were positively correlated with adiposity and traditional cardiometabolic risk factors (eg, serum insulin and triacylglyceride levels, all r ≥ 0.17 and P ≤ .045). Plasma levels of 2-arachidonoyl glycerol and N-pentadecenoylethanolamine were negatively correlated with BAT volume and glucose uptake (all r ≤ −0.17 and P ≤ .047). We observed that the plasma levels of eCBs and their analogues were higher in metabolically unhealthy overweight–obese participants than in metabolically healthy overweight–obese participants. Conclusion: Our findings show that the plasma levels of eCBs and their analogues are related to higher levels of adiposity and worse cardiometabolic profile. | es_ES |
dc.description.sponsorship | Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393) | es_ES |
dc.description.sponsorship | Spanish Ministry of Economy and Competitiveness (PTA-12264) | es_ES |
dc.description.sponsorship | Retos de la Sociedad (DEP2016-79512-R) | es_ES |
dc.description.sponsorship | European Regional Development Fund (ERDF) | es_ES |
dc.description.sponsorship | Spanish Ministry of Education (FPU16/02828, FPU17/01523 and FPU19/01609) | es_ES |
dc.description.sponsorship | Fundación Iberoamericana de Nutrición (FINUT) | es_ES |
dc.description.sponsorship | Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022) | es_ES |
dc.description.sponsorship | AstraZeneca HealthCare Foundation | es_ES |
dc.description.sponsorship | University of Granada Plan Propio de Investigación 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES) | es_ES |
dc.description.sponsorship | Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC 01151) | es_ES |
dc.description.sponsorship | Fundación Alfonso Martin Escudero | es_ES |
dc.description.sponsorship | Dutch Heart Foundation, Dutch Federation of University Medical Centers | es_ES |
dc.description.sponsorship | Netherlands Organization for Health Research and Development | es_ES |
dc.description.sponsorship | Royal Netherlands Academy of Arts and Sciences (CVON2017-20 GENIUS-2) | es_ES |
dc.description.sponsorship | China Scholarship Council (no. 201707060012) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Body composition | es_ES |
dc.subject | Cardiometabolic risk factors | es_ES |
dc.subject | Anandamide | es_ES |
dc.title | Higher Plasma Levels of Endocannabinoids and Analogues Correlate With a Worse Cardiometabolic Profile in Young Adults | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1210/clinem/dgad668 | |
dc.type.hasVersion | VoR | es_ES |