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Expression of the p53 protein in oral squamous cell carcinomas associated with Epstein-Barr virus
dc.contributor.author | González Moles, Miguel Ángel | |
dc.contributor.author | Galindo Moreno, Pablo Antonio | |
dc.contributor.author | Gutiérrez Fernández, José | |
dc.contributor.author | Rodríguez Archilla, Alberto | |
dc.contributor.author | Ruiz Ávila, María Isabel | |
dc.contributor.author | Sánchez Fernández, Elena | |
dc.date.accessioned | 2024-04-03T09:34:31Z | |
dc.date.available | 2024-04-03T09:34:31Z | |
dc.date.issued | 2000-01 | |
dc.identifier.citation | González-Moles MA, Galindo P, Gutierrez J, Rodriguez-Archilla A, Ruiz-Avilla I, Sanchez-Fernandez E. Expression of the p53 protein in oral squamous cell carcinomas associated with Epstein-Barr virus. Microbios. 2000;102(403):147-54. | es_ES |
dc.identifier.other | PMID: 10955828. | |
dc.identifier.uri | https://hdl.handle.net/10481/90356 | |
dc.description.abstract | The behaviour of the p53 protein has been investigated in some human carcinomas associated with Epstein-Barr virus (EBV) but not in EBV-positive oral squamous cell carcinomas (OSCC). The present study aimed to compare the p53 protein expression in EBV-positive OSCC with that in EBV-negative OSCC. The cases had been gathered in a study previously published. An immunohistochemical technique with BP53-12 monoclonal antibody was applied on 74 of the 107 OSCC from the earlier work. The nuclear or cytoplasmic expression of the p53 protein was classified as, absent (0% of neoplastic cells positive), mild (<25% positive), moderate (25-30% positive), or extensive (>50% positive). The p53 protein was expressed by 60.8% of the OSCC. Out of the fourteen EBV-positive OSCC, 57.1% (8 cases) expressed p53, always in the nucleus and never in the cytoplasm. Of the 60 EBV-negative OSCC, 61.6% (37 cases) expressed the p53 protein. Of 37 cases 33 (89.1%) showed nuclear expression of p53 and nineteen cases (51.3%) revealed cytoplasmic expression. There was a statistically significant inverse correlation between cytoplasmic expression of the p53 protein and the presence of EBV DNA (p <0.01). Thus, the EBV-positive tumours less frequently expressed p53 in the cytoplasm. No evidence of an accumulation of the p53 protein in OSCC associated with EBV was recorded. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | The Faculty Press | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Expression of the p53 protein in oral squamous cell carcinomas associated with Epstein-Barr virus | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |