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dc.contributor.authorGalocha-León, Cristina
dc.contributor.authorAntich Acedo, Cristina
dc.contributor.authorVoltes Martínez, Ana
dc.contributor.authorMarchal Corrales, Juan Antonio 
dc.contributor.authorMallandrich, Mireia
dc.contributor.authorHalbaut, L.
dc.contributor.authorRodríguez Lagunas, M.J.
dc.contributor.authorSouto, Eliana B.
dc.contributor.authorClares Naveros, Beatriz 
dc.contributor.authorGálvez Martín, P.
dc.date.accessioned2024-04-03T08:47:24Z
dc.date.available2024-04-03T08:47:24Z
dc.date.issued2023
dc.identifier.citationInternational Journal of Pharmaceutics 647 (2023) 123535 [10.1016/j.ijpharm.2023.123535]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/90347
dc.description.abstractWound healing is a natural physiological reaction to tissue injury. Hydrogels show attractive advantages in wound healing not only due to their biodegradability, biocompatibility and permeability but also because provide an excellent environment for cell migration and proliferation. The main objective of the present study was the design and characterization of a hydrogel loaded with human mesenchymal stromal cells (hMSCs) for use in would healing of superficial skin injures. Poloxamer 407® was used as biocompatible biomaterial to embed hMSCs. The developed hydrogel containing 20 % (w/w) of polymer resulted in the best formulation with respect to physical, mechanical, morphological and biological properties. Its high swelling capacity confirmed the hydrogel’s capacity to absorb wounds’ exudate. LIVE/DEAD® assay confirm that hMSCs remained viable for at least 48 h when loaded into the hydrogels. Adding increasing concentrations of hMSCs-loaded hydrogel to the epithelium did not affect keratinocytes’ viability and healing capacity and all wound area was closed in less than one day. Our study opens opportunities to exploit poloxamer hydrogels as cell carriers for the treatment of skin superficial wound.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHydrogeles_ES
dc.subjectPoloxameres_ES
dc.subjectHuman mesenchymal stromal cellses_ES
dc.titleDevelopment and characterization of a poloxamer hydrogel composed of human mesenchymal stromal cells (hMSCs) for reepithelization of skin injurieses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1016/j.ijpharm.2023.123535
dc.type.hasVersionVoRes_ES


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Atribución 4.0 Internacional
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