Infectious agents associated with schizophrenia: a meta-analysis
Metadatos
Afficher la notice complèteAuteur
Arias Horcajadas, María Isabel; Sorlozano Puerto, Antonio; Villegas Martínez, Enrique; Luna Del Castillo, Juan De Dios; McKenney, Kathryn; Cervilla Ballesteros, Jorge Antonio; Gutiérrez Martínez, Blanca; Gutiérrez Fernández, JoséEditorial
Elsevier
Materia
Schizophrenia Infection Meta-analysis
Date
2012-04Referencia bibliográfica
Arias I, Sorlozano A, Villegas E, de Dios Luna J, McKenney K, Cervilla J, Gutierrez B, Gutierrez J. Infectious agents associated with schizophrenia: a meta-analysis. Schizophr Res. 2012 Apr;136(1-3):128-36. https://doi.org/10.1016/j.schres.2011.10.026
Résumé
Schizophrenia is a highly disabling and limiting disorder for patients and the possibility that infections by some microorganisms may be associated to its development may allow prevention and recovery. In the current study we have done a meta-analysis of studies that have assessed the possible association between detection of different infectious agents and schizophrenia. We report results that support the idea that there is a statistically significant association between schizophrenia and infection by Human Herpesvirus 2 (OR=1.34; CI 95%: 1.09-1.70; p=0.05), Borna Disease Virus (OR=2.03; CI 95%: 1.35-3.06; p<0.01), Human Endogenous Retrovirus W (OR=19.31; CI 95%: 6.74-55.29; p<0.001), Chlamydophila pneumoniae (OR=6.34; CI 95%: 2.83-14.19; p<0.001), Chlamydophila psittaci (OR=29.05; CI 95%: 8.91-94.70; p<0.001) and Toxoplasma gondii (OR=2.70; CI 95%: 1.34-4.42; p=0.005). The implications of these findings are discussed and further research options are also explicated.