Activity of tigecycline against clinical isolates of Staphylococcus aureus and extended-spectrum β-lactamase-producing Escherichia coli in Granada, Spain
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Gutiérrez Fernández, José; Solorzano Puerto, Antonio; Luna Del Castillo, Juan De Dios; Salmerón, A.; Martínez-Checa Barrero, Fernando José; Román, J.; Piédrola Angulo, GonzaloEditorial
Elsevier
Date
2006-12Referencia bibliográfica
Sorlózano A, Gutiérrez J, Salmerón A, Luna JD, Martínez-Checa F, Román J, Piédrola G. Activity of tigecycline against clinical isolates of Staphylococcus aureus and extended-spectrum beta-lactamase-producing Escherichia coli in Granada, Spain. Int J Antimicrob Agents. 2006 Dec;28(6):532-6.
Abstract
We evaluated the in vitro activity of tigecycline using the Etest and disk diffusion method according to Clinical and Laboratory Standards Institute guidelines against clinical isolates of methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) as well as for CTX-M-9 extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and SHV ESBL-producing E. coli. All isolates were susceptible to tigecycline according to US Food and Drug Administration cut-off points. There were no differences in the activity of tigecycline between MSSA and MRSA isolates or between the presence of either type of ESBL. For each type of microorganism studied, we established the equation relating the minimum inhibitory concentration to the diameter of the zone of inhibition.