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Multiple sclerosis and human herpesvirus 6
dc.contributor.author | Gutiérrez Fernández, José | |
dc.contributor.author | Vergara Pavón, María José | |
dc.contributor.author | Guerrero, M. | |
dc.contributor.author | Fernández, O. | |
dc.contributor.author | Piédrola Angulo, Gonzalo | |
dc.contributor.author | Morales, Patricia | |
dc.contributor.author | Maroto Vela, María del Carmen | |
dc.date.accessioned | 2024-03-14T12:17:57Z | |
dc.date.available | 2024-03-14T12:17:57Z | |
dc.date.issued | 2002-06 | |
dc.identifier.citation | Gutiérrez, J., Vergara, MJ., Guerrero, M. et al. Multiple Sclerosis and Human Herpesvirus 6. Infection 30, 145–149 (2002). https://doi.org/10.1007/s15010-002-2056-7 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/89984 | |
dc.description | This study was supported by the Health Council of Andalusian Regional Goverments, project 141/2001 and the Spanish Federation of Multiple Sclerosis. | es_ES |
dc.description.abstract | Background: A possible but as yet unproven relationship has been proposed between the onset or persistence of multiple sclerosis (MS) symptoms and herpesviruses, including, most recently, human herpesvirus 6 (HHV-6). A study was conducted to investigate the presence of HHV-6 DNA and the synthesis of antibodies against HHV-6, cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in serum and cerebrospinal fluid (CSF) of patients with MS. Materials and methods: PCR and ELISA were used to detect HHV-6 DNA and specific antibodies against HHV-6, CMV and EBV in 211 samples (139 sera and 72 CSF). There were three groups of samples: group I, paired samples of serum and CSF from 41 MS patients; group II, paired samples of serum and CSF from 31 patients with neurological diseases other than MS (OND); group III, 67 serum samples from 27 different MS patients undergoing serologic follow-up. Results: No HHV-6 DNA was found in any sample. Group I sera showed elevated anti-HHV-6 IgG and IgA levels. In group II, anti-CMV IgG was detected in one CSF sample and anti-HHV-6 IgM in one serum sample. Group III sera showed high concentrations of anti-HHV-6 IgG, IgA and IgM. Conclusion: Given the clinical implications of the presence of antibodies against HHV-6 in MS patients, a viral reactivation cannot be excluded as an environmental factor. | es_ES |
dc.description.sponsorship | Health Council of Andalusian Regional Goverments, project 141/2001 | es_ES |
dc.description.sponsorship | Spanish Federation of Multiple Sclerosis | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Herpesvirus | es_ES |
dc.subject | Multiple sclerosis | es_ES |
dc.subject | HHV-6 | es_ES |
dc.subject | CMV | es_ES |
dc.subject | EBV | es_ES |
dc.title | Multiple sclerosis and human herpesvirus 6 | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1007/s15010-002-2056-7 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |