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dc.contributor.authorGarzón Bello, Ingrid Johanna 
dc.contributor.authorChato Astrain, Jesús 
dc.contributor.authorCampos Sánchez, Fernando 
dc.contributor.authorFernández Valadés, Ricardo 
dc.contributor.authorSánchez-Montesinos García, Indalecio 
dc.contributor.authorCampos Muñoz, Antonio Jesús 
dc.contributor.authorAlaminos Mingorance, Miguel 
dc.contributor.authorD'Souza, Rena N.
dc.contributor.authorMartín Piedra, Miguel Ángel 
dc.date.accessioned2024-03-14T07:48:06Z
dc.date.available2024-03-14T07:48:06Z
dc.date.issued2020
dc.identifier.citationPublished version: Garzon I, Chato-Astrain J, Campos F, Fernandez-Valades R, Sanchez-Montesinos I, Campos A, Alaminos M, D'Souza RN, Martin-Piedra MA. Expanded Differentiation Capability of Human Wharton's Jelly Stem Cells Toward Pluripotency: A Systematic Review. Tissue Eng Part B Rev. 2020 Aug;26(4):301-312. http://dx.doi.org/10.1089/ten.TEB.2019.0257es_ES
dc.identifier.urihttps://hdl.handle.net/10481/89967
dc.descriptionThis study was supported by the Spanish Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I+D+I) of the Spanish Ministry of Economy and Competitiveness (Instituto de Salud Carlos III), grants FIS PI17/0391, PI18/331 and PI18/332 (co-financed by ERDF-FEDER, European Union).es_ES
dc.description.abstractHuman Wharton’s jelly stem cells (HWJSC) can be efficiently isolated from the umbilical cord, and numerous reports have demonstrated that these cells can differentiate into several cell lineages. This fact, coupled with the high proliferation potential of HWJSC, make them a promising source of stem cells for use in tissue engineering and regenerative medicine. However, their real potentiality has not been established to date. In the present study we carried out a systematic review to determine the multilineage differentiation potential of HWJSC. After a systematic literature search we selected 32 publications focused on the differentiation potential of these cells. Analysis of these studies showed that HWJSC display expanded differentiation potential towards some cell types corresponding to all three embryonic cell layers (ectodermal, mesodermal and endodermal), which is consistent with their constitutive expression of key pluripotency markers such as OCT4, SOX2 and NANOG, and the embryonic marker SSEA4. We conclude that HWJSC can be considered cells in an intermediate state between multipotentiality and pluripotentiality, since their proliferation capability is not unlimited and differentiation to all cell types has not been demonstrated thus far. These findings support the clinical use of HWJSC for the treatment of diseases affecting not only mesoderm-type tissues, but also other cell lineages.es_ES
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness FIS PI17/0391, PI18/331, PI18/332es_ES
dc.description.sponsorshipERDF-FEDER, European Uniones_ES
dc.language.isoenges_ES
dc.publisherMary Ann Liebertes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 License
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectHuman Wharton’s jelly stem cellses_ES
dc.subjectAdvanced therapieses_ES
dc.subjectMultipotent, Pluripotentes_ES
dc.subjectSystematic reviewes_ES
dc.titleExpanded Differentiation Capability of Human Wharton's Jelly Stem Cells Toward Pluripotency: A Systematic Reviewes_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1089/ten.TEB.2019.0257
dc.type.hasVersionAMes_ES


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