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P53 protein expression in oral squamous cell carcinoma. Survival analysis
dc.contributor.author | González Moles, Miguel Ángel | |
dc.contributor.author | Galindo Moreno, Pablo Antonio | |
dc.contributor.author | Gutiérrez Fernández, José | |
dc.contributor.author | Sánchez Fernández, Elena | |
dc.contributor.author | Rodríguez Archilla, Alberto | |
dc.contributor.author | Ruiz Ávila, María Isabel | |
dc.contributor.author | Bravo Pérez, Manuel | |
dc.date.accessioned | 2024-03-12T08:47:55Z | |
dc.date.available | 2024-03-12T08:47:55Z | |
dc.date.issued | 2001-07 | |
dc.identifier.citation | Gonzalez-Moles MA, Galindo P, Gutierrez-Fernandez J, Sanchez-Fernandez E, Rodriguez-Archilla A, Ruiz-Avila I, Bravo M. P53 protein expression in oral squamous cell carcinoma. survival analysis. Anticancer Res. 2001 Jul-Aug;21 (4B): 2889-94. DOI: 10.4103/jomfp.JOMFP_106_20 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/89927 | |
dc.description.abstract | Background: The present study aimed to analyze the pattern of p53 expression and its influence on survival in patients with oral squamous cell carcinoma (OSCC). Materials and methods: An immunohistochemical technique with BP53-12 antibody was performed on stored tissue from 78 patients with OSCC (intraoral cancer n=40; lip cancer n=38). The nuclear and cytoplasmic extension of p53 staining was assessed. Clinical and histopathological data were gathered and the patient survival was analyzed. Results: 57.7% (n=45) of the OSCCs expressed p53, with nuclear expression in 52.6% (n=41) of cases and cytoplasmic expression in 24.4% (n=19). The OSCCs with extensive nuclear expression of p53 showed dissociated patterns of invasion of adjacent tissues (p<0.05). A greater extension of cytoplasmic expression of p53 most commonly appeared in tumors that were better-differentiated (p<0.005), more keratinized (p<0.01) and with less nuclear atypia (p<0.05). The parameters that significantly influenced survival of patients were tumor localization (p<0.01), size (p<0.0001), lymph node invasion (p<0.0001), clinical stage (p<0.0001), differentiation degree (p<0.01) and nucleargrade (p<0.01). Conclusion: The expression of p53 protein did not behave as a marker of prognostic value in patients with OSCC. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | National Library of Medicine | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Oral squamous cell carcinoma | es_ES |
dc.subject | P53 | es_ES |
dc.subject | Survival | es_ES |
dc.subject | Tumor-free margins | es_ES |
dc.title | P53 protein expression in oral squamous cell carcinoma. Survival analysis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.4103/jomfp.JOMFP_106_20 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |