Contribution of a new mutation in parE to quinolone resistance in extended-spectrum-beta-lactamase-producing Escherichia coli isolates

Sorlozano Puerto, Antonio; Gutiérrez Fernández, José; Jiménez Pacheco, Antonio; Luna Del Castillo, Juan De Dios; Martínez Torres, José Luis

doi:10.1128/JCM.01093-07

Sorloz-JClinMicrobiol45.pdf (44.57Kb)

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URI: https://hdl.handle.net/10481/89876

DOI: 10.1128/JCM.01093-07

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Editorial

American Society for Microbiolog

Date

2007-08

Referencia bibliográfica

Sorlozano A, Gutierrez J, Jimenez A, de Dios Luna J, Martínez JL. Contribution of a new mutation in parE to quinolone resistance in extended-spectrum-beta-lactamase-producing Escherichia coli isolates. J Clin Microbiol. 2007 Aug;45(8):2740-2.

Abstract

Mutations in the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE were studied in 30 fluoroquinolone-resistant clinical isolates of Escherichia coli producing extended-spectrum beta-lactamases. Ten isolates showed a mutation in parE that was significantly associated with an increase in the MIC for fluoroquinolones.

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