Mostrar el registro sencillo del ítem
The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility
dc.contributor.author | Merisalu, Ave | |
dc.contributor.author | Punab, Margus | |
dc.contributor.author | Altmäe, Signe | |
dc.contributor.author | Haller, Kadri | |
dc.contributor.author | Tiido, Tarmo | |
dc.contributor.author | Peters, Maire | |
dc.contributor.author | Salumets, Andres | |
dc.date.accessioned | 2024-02-04T17:27:40Z | |
dc.date.available | 2024-02-04T17:27:40Z | |
dc.date.issued | 2007-06-07 | |
dc.identifier.uri | https://hdl.handle.net/10481/88162 | |
dc.description.abstract | Objective: Todeterminewhetherthepolymorphismsinarylhydrocarbonreceptor(AHR),arylhydrocarbonrecep- tor repressor (AHRR), and aryl hydrocarbon receptor nuclear translocator (ARNT) genes are associated with male factor infertility. Design: An association study. Setting: University research laboratory and andrology clinic. Patient(s): ThesubjectswereinfertileEstonianmen(n1⁄4112)withazoospermiaoroligozoospermiaandcontrols (n 1⁄4 212) with normal sperm parameters. Intervention(s): Blood samples were obtained for DNA extraction and genotyping. MainOutcomeMeasure(s): AHR(Arg554Lys),AHRR(Pro185Ala),andARNT(G/Callele)polymorphismswere genotyped using allele-specific polymerase chain reaction. Allele and genotype frequencies were compared between infertile men and controls and separately in the normozoospermia, oligozoospermia, and azoospermia groups. Result(s): The AHRR Ala185Ala genotype was implicated in susceptibility to male factor infertility. Ala/Ala genotype frequency increased in the following order: normozoospermia (18.0%), oligozoospermia (26.0%), azoospermia (42.1%). Allele and genotype frequencies of AHR and ARNT polymorphisms were similar between cases and controls. Conclusion(s): WedemonstratedthattheAHRRPro185Alapolymorphismcontributedtoapredispositiontomale factor infertility in the Estonian population. A greater prevalence of the Ala/Ala genotype was found among infer- tile patients. | es_ES |
dc.language.iso | eng | es_ES |
dc.title | The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1016/j.fertnstert.2006.12.041 | |
dc.type.hasVersion | info:eu-repo/semantics/submittedVersion | es_ES |