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Inorganic mesoporous silicas as vehicles of two novel anthracene-based ruthenium metalloarenes
dc.contributor.author | Rojas Macías, Sara | |
dc.contributor.author | Carmona Fernández, Francisco Jesús | |
dc.contributor.author | Barea Martínez, Elisa María | |
dc.contributor.author | Rodríguez Maldonado, Carmen | |
dc.date.accessioned | 2024-02-04T14:54:28Z | |
dc.date.available | 2024-02-04T14:54:28Z | |
dc.date.issued | 2017-01-01 | |
dc.identifier.citation | J. Inorg. Biochem. 2017, 166, 87-93 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/88086 | |
dc.description | Version aceptada / Accepted version | es_ES |
dc.description.abstract | Two novel anthracene-based half-sandwich organometallic Ru(II) compounds, namely, [Ru(p-cymene)(L1)Cl2] (1) and [Ru(p-cymene)(L2)Cl2] (2) (L1 = 1-(anthracen-9-yl)-N-(pyridin-3-ylmethyl)methanamine; L2 = 1-(anthracen-9-yl)-N-(pyridin-4-ylmethyl)methanamine) have been synthesized and characterized. We demonstrate that the fluorescence properties of these complexes are highly affected by the linking position of the anthracene unit, as only 2 shows fluorescence emission in the blue region. Regarding their biological activity, both ruthenium metallodrugs show interaction with different biological targets such as S-donor amino acids (cysteine) and proteases (cysteine cathepsin B). Moreover, 1 and 2 show in vitro cytotoxicity against HL-60 cancer cell line (IC50 = 84.5 and 87.0 μM for 1 and 2, respectively), with cell death occurring via apoptosis. Further studies have shown that diffusion into cells is the main mechanism of metallodrug uptake. Finally, as a proof of concept, these ruthenium complexes have been successfully encapsulated into MCM-41 and SBA-15 mesoporous silicas using two different incorporation strategies (impregnation and grinding). | es_ES |
dc.description.sponsorship | The Spanish Ministry of Economy and Competitiveness and UE Feder Program (projects CTQ2014-53486R and CRM Juan de la Cierva Contract), Junta de Andalucía (project P09-FQM-4981 and SR postdoctoral contract), CEI BioTic Granada (project CEI2015-MP-BS39) and COST action CM1105 are gratefully acknowledged for generous funding. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Inorganic mesoporous silicas as vehicles of two novel anthracene-based ruthenium metalloarenes | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1016/j.jinorgbio.2016.11.004 |