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miR-430 microRNA Family in Fishes: Molecular Characterization and Evolution
dc.contributor.author | Jiménez-Ruiz, Claudio Amador | |
dc.contributor.author | Herrán Moreno, Roberto De La | |
dc.contributor.author | Robles Rodríguez, Francisca | |
dc.contributor.author | Navajas Pérez, Rafael | |
dc.contributor.author | Cross, Ismael | |
dc.contributor.author | Rebordinos, Laureana | |
dc.contributor.author | Ruiz Rejón, Carmelo | |
dc.date.accessioned | 2024-01-19T08:16:17Z | |
dc.date.available | 2024-01-19T08:16:17Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Jiménez-Ruiz, C.A.; de la Herrán, R.; Robles, F.; Navajas-Pérez, R.; Cross, I.; Rebordinos, L.; Ruiz-Rejón, C. miR-430 microRNA Family in Fishes: Molecular Characterization and Evolution. Animals 2023, 13, 2399. https://doi.org/10.3390/ani13152399 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/86934 | |
dc.description | This research was funded by the Spanish Ministry of Economy and Competitiveness, FEDER, grant number RTI2018-096847-B-C22, and Regional Government of Andalusia—FEDER Grant: P20-00938. | es_ES |
dc.description.abstract | The miR-430 microRNA family has been described in multiple fish species as one of the first microRNAs expressed by the zygote. It has been suggested that this family is implicated in maternal mRNA elimination, but may also play a role in steroidogenesis, sexual differentiation, and flatfish metamorphosis. The miR-430 sequences have been found in multiple-copy tandem clusters but evidence of their conservation outside of teleost fishes is scarce. In the present study, we have characterized the tandem repeats organization of these microRNAs in different fish species, both model and of interest in aquaculture. A phylogenetic analysis of this family has allowed us to identify that the miR-430 duplication, which took place before the Chondrostei and Neopterygii groups’ divergence, has resulted in three variants (“a”, “b”, and “c”). According to our data, variant “b” is the most closely related to the ancestral sequence. Furthermore, we have detected isolated instances of the miR-430 repeat subunit in some species, which suggests that this microRNA family may be affected by DNA rearrangements. This study provides new data about the abundance, variability, and organization of the miR-430 family in fishes. | es_ES |
dc.description.sponsorship | Departamento de Genética. Grupo BIO200. Facultad de Ciencias. Universidad de Granada | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | es_ES |
dc.subject | Noncoding RNA | es_ES |
dc.subject | Tandem repeats | es_ES |
dc.subject | Genomic organization | es_ES |
dc.title | miR-430 microRNA Family in Fishes: Molecular Characterization and Evolution | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/ani13152399 | |
dc.type.hasVersion | VoR | es_ES |