Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study
Metadata
Show full item recordEditorial
Frontiers Media
Materia
MicroRNA HIV NAFLD CAP PLWH Steatosis
Date
2023-09-22Referencia bibliográfica
Frías M, Corona-Mata D, Moyano JM, Camacho-Espejo A, López-López P, Caballero-Gómez J, Ruiz-Cáceres I, Casares-Jiménez M, Pérez-Valero I, Rivero-Juárez A and Rivero A (2023) Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study. Front. Endocrinol. 14:1230046. [doi: 10.3389/fendo.2023.1230046]
Sponsorship
Secretarı́a General de Investigación, Desarrollo e Innovación en Salud (PI-0287-2019); Ministerio de Sanidad RD12/0017/0012; European Union (EU); (FIS) del Instituto Carlos III PI18/01270; Miguel Servet Research Contract by the Ministerio de Ciencia, Promocin y Universidades of Spain CP18/00111; CIBER -Consorcio Centro de Investigación Biomédica en Red-CB21/13/00083; Instituto de Salud Carlos III (ISCIII) - European Union CM22/00176 Rio-Hortega; MCIN/AEI/10.13039/501100011033; European Union NextGenerationEU/PRTR - NextGeneration EUAbstract
Background & objective: Nonalcoholic fatty liver disease (NAFLD) is highly
prevalent in people living with HIV (PLWH) and the expression of some
microRNAs could be useful as biomarkers for the diagnosis of NAFLD. The aim
of this study was to identify patterns of differential expression of microRNAs in
PLWH and assess their diagnostic value for NALFD.
Methods: A discovery case-control study with PLWH was carried out. The
expression of miRNAs was determined using HTG EdgeSeq technology. Cases
were defined as patients with severe NAFLD and controls as patients without
NAFLD, characterized using the controlled attenuation parameter (CAP). Cases
and controls were matched 1:1 for age, sex, BMI, CD4+ lymphocyte count, active
HCV infection, and ART regimen.
Results: Serum 2,083 simultaneous microRNA transcripts were analyzed using
HTG technology and compared between cases and controls. Forty-five patients,
23 cases, and 22 controls were included in the study. In the analysis of the
expression pattern of the 2,083 microRNAs, no differential expression patterns
were found between both groups of patients included in the study.
Conclusion: Analysis of the microRNA transcriptome profile of nonobese PLWH
with severe NAFLD did not appear to differ from that of patients without NAFLD.
Thus, microRNA might not serve as a proper biomarker for predicting severe
NALFD in this population.