Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells
Metadatos
Mostrar el registro completo del ítemEditorial
MDPI
Materia
Cáncer Lung cancer Selectivity Xiphion xiphium Iris xiphium Iridaceae
Fecha
2023-09-15Referencia bibliográfica
Jiménez-González, V.; Benítez, G.; Pastor, J.E.; López-Lázaro, M.; Calderón-Montaño, J.M. Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells. Plants 2023, 12, 3275. [https://doi.org/10.3390/plants12183275]
Patrocinador
Junta de Andalucía (grant numbers 2017/CTS-657; 2019/CTS-657; and 2021/CTS-657); University of Seville through the “VI Plan Propio de Investigación y Transferencia” (grant numbers VIPPIT-2019-I.5, VIPPIT-2020-I.5, and VIPPIT-2021-I)Resumen
Every year, cancer kills millions of people around the world. Finding more selective
anticancer agents is essential to improve the low survival rates of patients with metastatic cancers.
Since the research of natural products is a valuable approach to the discovery of new compounds
and the Iberian flora offers a rich source of unstudied plants, we have carried out a random
screening of 76 plant species from 43 families collected in Andalusia (South of Spain). Using nonmalignant
cells (HaCaT) and lung cancer cells (A549), we found that the extract from Arum italicum
Mill. subsp. italicum (Araceae), Mandragora autumnalis Bertol. (Solanaceae), Rhamnus alaternus L.
(Rhamnaceae), and Lomelosia simplex (Desf.) Raf. subsp. dentata (Jord. & Fourr.) Greuter & Burdet
(Dipsacaceae) showed selective cytotoxicity against lung cancer cells. Extracts of plant species
belonging to the Iridaceae family showed high selective activity against cancer cells, highlighting
that the Xiphion xiphium (L.) M.B. Crespo, Mart.-Azorín & Mavrodiev flower extract was more
selective against lung cancer cells than the standard anticancer drugs, cisplatin and 5-fluorouracil.
This extract also showed modest selective cytotoxicity against bladder carcinoma cells (T24). The
number of cells in the G1 phase increased after treatment with the extract from Xiphion xiphium.
Our research indicates that various plants are potential sources for the isolation and development
of new anticancer drugs.