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Moving into the red – a near infra-red optical probe for analysis of human neutrophil elastase in activated neutrophils and neutrophil extracellular traps
dc.contributor.author | Rodriguez Rios, Maria | |
dc.contributor.author | Megía Fernández, Alicia | |
dc.date.accessioned | 2023-10-25T10:23:16Z | |
dc.date.available | 2023-10-25T10:23:16Z | |
dc.date.issued | 2023-09 | |
dc.identifier.citation | Chem. Commun., 2023, 59, 11660[DOI: 10.1039/d3cc03634k] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/85243 | |
dc.description.abstract | Neutrophils are the first immune cells recruited for defence against invading pathogens; however, their dysregulated activation and subsequent release of the enzyme human neutrophil elastase is associated with several, inflammation-based, diseases. Herein, we describe a FRET-based, tri-branched (one quencher, three fluorophores) near infrared probe that provides an intense OFF/ON amplified fluorescence signal for specific detection of human neutrophil elastase. The probe allowed selective detection of activated neutrophils and labelling of neutrophil extracellular traps. A tri-branched, FRET-based probe for the detection of hNE was synthesised with emission in the NIR region of the spectrum, where endogenous biomolecules have decreased absorbance, and minimal autofluorescence | es_ES |
dc.description.sponsorship | UK Research & Innovation (UKRI) Engineering & Physical Sciences Research Council (EPSRC) EP/R005257/1 | es_ES |
dc.description.sponsorship | UK Research & Innovation (UKRI) Medical Research Council UK (MRC) MR/N02995X/1 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Moving into the red – a near infra-red optical probe for analysis of human neutrophil elastase in activated neutrophils and neutrophil extracellular traps | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1039/d3cc03634k | |
dc.type.hasVersion | VoR | es_ES |