Multi-stimuli-responsive chitosan-functionalized magnetite/poly(ε-caprolactone) nanoparticles as theranostic platforms for combined tumor magnetic resonance imaging and chemotherapy
Metadata
Show full item recordEditorial
Elsevier
Materia
Chitosan Dual pH- and heat-triggered drug release Magnetic resonance imaging Magnetite Poly(ε-caprolactone)
Date
2023-08Referencia bibliográfica
G. García-García et al / Nanomedicine: Nanotechnology, Biology, and Medicine 52 (2023) 102695[https://doi.org/10.1016/j.nano.2023.102695]
Sponsorship
FEDER/Junta de Andalucía – Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Spain (Grant P20_00346); Universidad de Granada / Consorcio de Bibliotecas Universitarias de Andalucía (CBUA), SpainAbstract
Chitosan-functionalized magnetite/poly(ε-caprolactone) nanoparticles were formulated by interfacial polymer disposition plus coacervation,
and loaded with gemcitabine. That (core/shell)/shell nanostructure was confirmed by electron microscopy, elemental analysis, electrophoretic,
and Fourier transform infrared characterizations. A short-term stability study proved the protection against particle aggregation
provided by the chitosan shell. Superparamagnetic properties of the nanoparticles were characterized in vitro, while the definition of the
longitudinal and transverse relaxivities was an initial indication of their capacity as T2 contrast agents. Safety of the particles was demonstrated
in vitro on HFF-1 human fibroblasts, and ex vivo on SCID mice. The nanoparticles demonstrated in vitro pH- and heat-responsive gemcitabine
release capabilities. In vivo magnetic resonance imaging studies and Prussian blue visualization of iron deposits in tissue samples defined the
improvement in nanoparticle targeting into the tumor when using a magnetic field. This tri-stimuli (magnetite/poly(ε-caprolactone))/chitosan
nanostructure could find theranostic applications (biomedical imaging & chemotherapy) against tumors.