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dc.contributor.authorHerrera Quintana, Lourdes María 
dc.contributor.authorVázquez Lorente, Héctor 
dc.contributor.authorGamarra Morales, Yenifer
dc.identifier.citationHerrera-Quintana, L.; Vázquez-Lorente, H.; Gamarra-Morales, Y.; Molina-López, J.; Planells, E. Evolution of Status of Trace Elements and Metallothioneins in Patients with COVID-19: Relationship with Clinical, Biochemical, and Inflammatory Parameters. Metabolites 2023, 13, 931. [ metabo13080931]es_ES
dc.description.abstractThe inflammatory reaction and pathogenesis of COVID-19 may be modulated by circulating trace elements (Iron (Fe), Zinc (Zn), Copper (Cu), Manganese (Mn)) and Metallothioneins (MTs). Thus, the present study aimed to investigate their relationship with clinical, biochemical, and inflammatory parameters in patients with COVID-19 at the early Intensive Care Unit (ICU) phase. Critically ill patients (n = 86) were monitored from the first day of ICU admission until the third day of stay. Serum samples were used to assess mineral levels via Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and MT levels via differential pulse voltammetry. Levels of Cu and MTs were significantly decreased after 3 days (p < 0.05), increasing the prevalence of Cu-deficient values from 50% to 65.3% (p = 0.015). Fe and Zn were shown to have a predictive value for mortality and severity. The present study suggests trace element deficiency may be a risk factor during early ICU treatment of COVID-19, as it is related to different biochemical and clinical parameters, indicating a possible beneficial effect of restoring proper levels of these micronutrients.es_ES
dc.description.sponsorshipEuropean Regional Development Fund (ERDF) “a way of making Europe”es_ES
dc.description.sponsorshipConsejería de Transformación Económica, Industria, Conocimiento y Universidades de la Junta de Andalucía (REF. A-CTS-708-UGR20)es_ES
dc.description.sponsorshipProject FIS PI10/1993 from the Spanish Carlos III Health Institutees_ES
dc.description.sponsorship(REF. FPU18/03702)es_ES
dc.description.sponsorship(REF. FPU18/03655)es_ES
dc.description.sponsorshipSpanish Ministry of Educationes_ES
dc.rightsAtribución 4.0 Internacional*
dc.subjectIron es_ES
dc.subjectZinc es_ES
dc.subjectCopper es_ES
dc.subjectManganese es_ES
dc.subjectMetallothionein es_ES
dc.subjectCritical carees_ES
dc.titleEvolution of Status of Trace Elements and Metallothioneins in Patients with COVID-19: Relationship with Clinical, Biochemical, and Inflammatory Parameterses_ES
dc.identifier.doi10.3390/ metabo13080931

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Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional