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Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study
dc.contributor.author | Almanza Aguilera, Enrique | |
dc.contributor.author | Sánchez Pérez, María José | |
dc.date.accessioned | 2023-10-16T09:11:51Z | |
dc.date.available | 2023-10-16T09:11:51Z | |
dc.date.issued | 2023-08-11 | |
dc.identifier.citation | Almanza-Aguilera, E.; Guiñón-Fort, D.; Perez-Cornago, A.; Martínez-Huélamo, M.; Andrés-Lacueva, C.; Tjønneland, A.; Eriksen, A.K.; Katzke, V.; Bajracharya, R.; Schulze, M.B.; et al. Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study. Cancers 2023, 15, 4067. [https://doi.org/10.3390/cancers15164067] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/85008 | |
dc.description.abstract | Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 lowgrade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94–1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence. | es_ES |
dc.description.sponsorship | La Marato de TV-3 553/C/2019 PID2020-114921RB-C21 PI18/0191 PI22/0412 | es_ES |
dc.description.sponsorship | CIBERFES CB16/10/00269 | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III Spanish Government | es_ES |
dc.description.sponsorship | European Union (EU) | es_ES |
dc.description.sponsorship | Generalitat de Catalunya's Agency AGAUR 2021SGR00687 | es_ES |
dc.description.sponsorship | Maria de Maeztu Unit of Excellence CEX2021-001234-M | es_ES |
dc.description.sponsorship | MICIN/AEI/FEDER, UE | es_ES |
dc.description.sponsorship | European Union (EU) 2005328 | es_ES |
dc.description.sponsorship | Department of Epidemiology and Biostatistics, School of Public Health | es_ES |
dc.description.sponsorship | Danish Cancer Society | es_ES |
dc.description.sponsorship | Ligue nationale contre le cancer | es_ES |
dc.description.sponsorship | Institut Gustave Roussy | es_ES |
dc.description.sponsorship | Mutuelle Generale de l'Education Nationale | es_ES |
dc.description.sponsorship | Institut National de la Sante et de la Recherche Medicale (Inserm) | es_ES |
dc.description.sponsorship | Deutsche Krebshilfe | es_ES |
dc.description.sponsorship | Helmholtz Association | es_ES |
dc.description.sponsorship | German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) | es_ES |
dc.description.sponsorship | Federal Ministry of Education & Research (BMBF) | es_ES |
dc.description.sponsorship | Fondazione AIRC per la ricerca sul cancro | es_ES |
dc.description.sponsorship | Compagnia di San Paolo | es_ES |
dc.description.sponsorship | Dutch Ministry of Public Health, Welfare and Sports (VWS) | es_ES |
dc.description.sponsorship | Netherlands Cancer Registry (NKR) | es_ES |
dc.description.sponsorship | LK Research Funds | es_ES |
dc.description.sponsorship | Dutch Prevention Funds | es_ES |
dc.description.sponsorship | Netherlands Organization for Scientific Research (NWO) | es_ES |
dc.description.sponsorship | Health Research Fund (FIS)-Instituto de Salud Carlos III (ISCIII) | es_ES |
dc.description.sponsorship | Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra | es_ES |
dc.description.sponsorship | Catalan Institute of Oncology-ICO (Spain) | es_ES |
dc.description.sponsorship | Swedish Cancer Society | es_ES |
dc.description.sponsorship | Swedish Research Council and County Councils of Skane and Vaesterbotten (Sweden) | es_ES |
dc.description.sponsorship | Cancer Research UK 14136 C8221/A29017 | es_ES |
dc.description.sponsorship | UK Research & Innovation (UKRI) Medical Research Council UK (MRC) 1000143 MR/M012190/1 | es_ES |
dc.description.sponsorship | Sara Borrell CPII20/00009 | es_ES |
dc.description.sponsorship | Generalitat de Catalunya's Agency AGAUR 2021SGR00481 | es_ES |
dc.description.sponsorship | Miguel Servet II | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III Spanish Government | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Polyphenols | es_ES |
dc.subject | Diet | es_ES |
dc.subject | Intake | es_ES |
dc.subject | Prostate | es_ES |
dc.subject | Cancer | es_ES |
dc.subject | EPIC | es_ES |
dc.title | Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/UE/2005328 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/ESF/CD20/00071 | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.3390/ cancers15164067 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
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