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dc.contributor.authorYamamoto, Hideaki
dc.contributor.authorBuendía, Víctor
dc.contributor.authorMuñoz Martínez, Miguel Ángel 
dc.date.accessioned2023-10-09T16:37:10Z
dc.date.available2023-10-09T16:37:10Z
dc.date.issued2023-08-25
dc.identifier.citationYamamoto et al. Modular architecture facilitates noise-driven control of synchrony in neuronal networks. Sci. Adv. 9, eade1755 (2023). [DOI: 10.1126/sciadv.ade1755]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/84919
dc.descriptionH.Y., A.H.-I., and S.S. acknowledge MEXT Grant-in-Aid for Transformative Research Areas (B) “Multicellular Neurobiocomputing” (21H05164), JSPS KAKENHI (18H03325, 19H00846, 20H02194, 20K20550, 22H03657, 22K19821, 22KK0177, and 23H03489), JST-PRESTO (JMPJPR18MB), JST-CREST (JPMJCR19K3), and Tohoku University RIEC Cooperative Research Project Program for financial support. F.P.S., V.P., and J.Z. received support from the Max-Planck-Society. F.P.S. acknowledges funding by SMARTSTART, the joint training program in computational neuroscience by the VolkswagenStiftung and the Bernstein Network. F.P.S. and V.P. were funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG), SFB-1528–Cognition of Interaction. V.P. was supported by the DFG under Germany’s Excellence Strategy EXC 2067/1- 390729940. V.B. and A.L. were supported by a Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation, endowed by the Federal Ministry of Education and Research. A.L. is a member of the Machine Learning Cluster of Excellence EXC 2064/1- 39072764. M.A.M. acknowledges the Spanish Ministry and Agencia Estatal de investigación (AEI) through Project of I + D + i (PID2020-113681GB-I00), financed by MICIN/AEI/10.13039/501100011033 and FEDER “A way to make Europe”, and the Consejería de Conocimiento, Investigación Universidad, Junta de Andalucía and European Regional Development Fund (P20-00173) for financial support. J.Z. received financial support from the Joachim Herz Stiftung. J.S. acknowledges Horizon 2020 Future and Emerging Technologies (grant agreement 964877-NEUChiP), Ministerio de Ciencia, Innovación y Universidades (PID2019-108842GB-C21), and Departament de Recerca i Universitats, Generalitat de Catalunya (2017-SGR-1061 and 2021-SGR-00450) for financial support.es_ES
dc.descriptionSupplementary Materials This PDF file includes: Supplementary Text, file:///D:/Modular-architecture-facilitates-.pdfes_ES
dc.description.abstractHigh-level information processing in the mammalian cortex requires both segregated processing in specialized circuits and integration across multiple circuits. One possible way to implement these seemingly opposing demands is by flexibly switching between states with different levels of synchrony. However, the mechanisms behind the control of complex synchronization patterns in neuronal networks remain elusive. Here, we use precision neuroengineering to manipulate and stimulate networks of cortical neurons in vitro, in combination with an in silico model of spiking neurons and a mesoscopic model of stochastically coupled modules to show that (i) a modular architecture enhances the sensitivity of the network to noise delivered as external asynchronous stimulation and that (ii) the persistent depletion of synaptic resources in stimulated neurons is the underlying mechanism for this effect. Together, our results demonstrate that the inherent dynamical state in structured networks of excitable units is determined by both its modular architecture and the properties of the external inputs.es_ES
dc.description.sponsorshipD+i: P20-00173, PID2020-113681GB-I00es_ES
dc.description.sponsorshipInnovación y Universidades PID2019-108842GB-C21es_ES
dc.description.sponsorshipHorizon2020 Future and Emerging Technologies 964877-NEUChiPes_ES
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (PID2019-108842GB-C21)es_ES
dc.description.sponsorshipDepartament de Recerca i Universitats, Generalitat de Catalunya (2017-SGR-1061, 2021-SGR-00450)es_ES
dc.description.sponsorshipMICIN/AEI/10.13039/501100011033es_ES
dc.description.sponsorshipFEDER “A way to make Europe”es_ES
dc.description.sponsorshipJunta de Andalucíaes_ES
dc.description.sponsorshipEuropean Regional Development Fundes_ES
dc.language.isoenges_ES
dc.publisherAmerican Association for the Advancement of Sciencees_ES
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titleModular architecture facilitates noise-driven control of synchrony in neuronal networkses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/964877-NEUChiPes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1126/sciadv.ade1755
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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