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dc.contributor.authorLozano, Manuel
dc.contributor.authorGil Hernández, Fernando 
dc.contributor.authorOlmedo Palma, Pablo 
dc.date.accessioned2023-09-28T11:31:21Z
dc.date.available2023-09-28T11:31:21Z
dc.date.issued2023-08-22
dc.identifier.citationLozano, M., Broberg, K., Soler-Blasco, R. et al. Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems. Expo Health (2023). [https://doi.org/10.1007/s12403-023-00585-6]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/84721
dc.descriptionOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. We are grateful to all the participants and their families for taking part in this study. We also appreciate the generous contribution in the study of all INMA members. A full roster of the INMA Project researchers can be found at http://www.proyectoinma.org/presentacion-inma/listado-investigadores/en_listado-investigadores.html. This study was supported by grants from Spanish government through the Ministry of Universities under the grant CAS21/00008 and grant for the requalification of the Spanish University, financed by the European Union, NextGeneration EU, Instituto de Salud Carlos III [FIS-FEDER: 13/1944, 16/1288, 17/00663 and 19/1338; FIS-FSE: 17/00260; Miguel Servet-FSE: MSII20/0006, FIS-PI06/0867, FIS-PI09/00090, CPII18/00018], CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089, 2015111065), Generalitat Valenciana [BEST/2020/059, AICO/2020/285 and CIAICO/2021/132] and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221 and DFG 89/17). We also acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the "Centro de Excelencia Severo Ochoa 2019-2023" Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.es_ES
dc.description.abstractEmotional and behavioral problems during childhood raise the risk of subsequent developmental of mental disorders. Our aim was to study the association between maternal metal and trace element concentrations during gestation and these problems in 9 year-old children. The study sample comprised Spanish mother-child pairs in the INMA project (n = 1003). Metals and trace elements (As, Cd, Co, Cu, Mo, Ni, Pb, Sb, Se, Tl and Zn) were measured in urine samples collected during pregnancy. Inorganic As metabolites were speciated in a subsample (n = 729). Emotional and behavioral problems were assessed using the Child Behavior Checklist (CBCL) composed of three scales: internalizing, externalizing and total problems. Sociodemographic, dietary and exposure to other environmental pollutants were obtained through questionnaires. Single nucleotide polymorphisms in brain- and metabolism-related genes APOE, BDNF, GSTP1, and PON1 were determined in cord blood. Multivariate negative binomial models were used. The interaction with sex and genotypes was evaluated including interaction terms. A multi-element analysis was carried out by a principal component analysis. Higher concentrations of Cu, monomethylarsonic acid, and Pb during pregnancy were associated with an increased incidence ratio risk (IRR) between 4.6 and 7.5% for internalizing and externalizing problems for all three CBCL scales in the children. Increasing Mo, Ni and Co concentrations were associated with higher IRR for internalizing problems (up to 8%), and Cd for externalizing problems (6.7%). Modifications by sex and genotypes were found for several associations. Multi-element analysis associated multiple metals and trace elements (Ni, Cu, Se, Cd and Pb) with higher internalizing problems.es_ES
dc.description.sponsorshipCRUE-CSIC agreementes_ES
dc.description.sponsorshipSpanish government through the Ministry of Universities CAS21/00008es_ES
dc.description.sponsorshipSpanish Universityes_ES
dc.description.sponsorshipEuropean Union (EU)es_ES
dc.description.sponsorshipNextGeneration EUes_ES
dc.description.sponsorshipInstituto de Salud Carlos III Spanish Government 13/1944, 16/1288, 17/00663, 19/1338es_ES
dc.description.sponsorshipFIS-FSE 17/00260es_ES
dc.description.sponsorshipMiguel Servet-FSE MSII20/0006, FIS-PI06/0867, FIS-PI09/00090, CPII18/00018es_ES
dc.description.sponsorshipCIBERESPes_ES
dc.description.sponsorshipDepartment of Health of the Basque Government 2005111093, 2009111069, 2013111089, 2015111065es_ES
dc.description.sponsorshipCenter for Forestry Research & Experimentation (CIEF) BEST/2020/059, AICO/2020/285, CIAICO/2021/132es_ES
dc.description.sponsorshipProvincial Government of Gipuzkoa DFG06/002, DFG08/001, DFG15/221, DFG 89/17es_ES
dc.description.sponsorshipSpanish Governmentes_ES
dc.description.sponsorshipState Research Agency CEX2018-000806-Ses_ES
dc.description.sponsorshipGeneralitat de Catalunya through the CERCA Programes_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMetals es_ES
dc.subjectArsenic speciationes_ES
dc.subjectTrace elements es_ES
dc.subjectEmotional and behavioral problemses_ES
dc.subjectPrenatal exposurees_ES
dc.titlePrenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problemses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1007/s12403-023-00585-6
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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