Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis
Metadatos
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MDPI
Materia
Ketorolac Gel Hydrogels Alginate Sialolithiasis Mucosa; Inflammation
Fecha
2023-05-16Referencia bibliográfica
Silva, C.; Ramos-Yacasi, G.; Mallandrich, M.; Colom-Codina, H.; Suñer-Carbó, J.; Pérez-González, N.; Calpena, A.C.; Fernández-Campos, F. Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis. Gels 2023, 9, 415. https://doi.org/10.3390/ gels9050415
Resumen
Sialolithiasis mainly affects the oral salivary glands due to the presence of small stones
that obstruct the secretion of saliva. The treatment and control of pain and inflammation during the
course of this pathology is essential to guarantee the patient’s comfort. For this reason, a ketorolac
calcium cross-linked alginate hydrogel was developed, and it was then applied in the area of the
buccal cavity. The formulation was characterized (swelling and degradation profile, extrusion,
extensibility, surface morphology, viscosity, and drug release). The drug release was studied ex
vivo in static Franz cells and with a dynamic ex vivo method under artificial saliva continuous flow.
The product exhibits adequate physicochemical properties considering the intended purpose, and
the drug concentrations retained in the mucosa were high enough to deliver a therapeutic local
concentration able to reduce the pain associated with the patient’s conditions. The results confirmed
the suitability of the formulation for application in the mouth.