Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)
Metadatos
Mostrar el registro completo del ítemEditorial
Wiley
Materia
Artificial sweeteners Aspartame Cancer risk Case-control
Fecha
2023-06-16Referencia bibliográfica
Palomar-Cros A, Straif K, Romaguera D, et al. Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain). Int. J. Cancer. 2023;1–15. [DOI: 10.1002/ijc.34577]
Patrocinador
AGAUR 2014SGR850, 2017SGR1085, 2017SGR723, 2021SGR01354; Catalan Government‐Agency for Management of University and Research Grants; Centro de Excelencia Severo Ochoa 2019‐2023; Consejería de Salud of the Junta de Andalucía PI‐0306‐2011; Consejería de Sanidad de la Región de Murcia; Regional Government of the Basque Country; Conselleria de Sanitat of the Generalitat Valenciana 2010ACUP 00310, AP_061/10; EI FSE; European Commission grants FOOD-CT- 2006-036224-HIWATE; Fundación Caja de Ahorros de Asturias; Fundación Marqués de Valdecilla API 10/09; Generalitat de Catalunya; ICGC International Cancer Genome Consortium CLL; Instituto de Salud Carlos III‐FEDER PI08/0533, PI08/1359, PI08/1770, PI11/00226, PI11/01403, PI11/01810, PI11/01889, PI11/02213, PI12/00150, PI12/00265, PI12/00488, PI12/00715, PI12/01270, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI17CIII/00034, PS09/00773, PS09/01286, PS09/01662, PS09/02078; Junta de Castilla y León LE22A10‐2; MCIN; MINECO; RTICC RD12/0036/0036; Red Temática de Investigación del Cáncer; Spanish Association Against Cancer (AECC) Scientific Foundation; Spanish Ministry of Economy PRE2019‐089038; Spanish Ministry of Science and Innovation; University of OviedoResumen
Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.