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dc.contributor.authorVinkler, Michal
dc.contributor.authorGómez Samblás, María Mercedes
dc.identifier.citationVinkler, M., Fiddaman, S. R., Těšický, M., O'Connor, E. A., Savage, A. E., Lenz, T. L., ... & Westerdahl, H. (2023). Understanding the evolution of immune genes in jawed vertebrates. Journal of Evolutionary Biology.[DOI: 10.1111/jeb.14181]es_ES
dc.description.abstractDriven by co-evolution with pathogens, host immunity continuously adapts to optimize defence against pathogens within a given environment. Recent advances in genetics, genomics and transcriptomics have enabled a more detailed investigation into how immunogenetic variation shapes the diversity of immune responses seen across domestic and wild animal species. However, a deeper understanding of the diverse molecular mechanisms that shape immunity within and among species is still needed to gain insight into—and generate evolutionary hypotheses on—the ultimate drivers of immunological differences. Here, we discuss current advances in our understanding of molecular evolution underpinning jawed vertebrate immunity. First, we introduce the immunome concept, a framework for characterizing genes involved in immune defence from a comparative perspective, then we outline how immune genes of interest can be identified. Second, we focus on how different selection modes are observed acting across groups of immune genes and propose hypotheses to explain these differences. We then provide an overview of the approaches used so far to study the evolutionary heterogeneity of immune genes on macro and microevolutionary scales. Finally, we discuss some of the current evidence as to how specific pathogens affect the evolution of different groups of immune genes. This review results from the collective discussion on the current key challenges in evolutionary immunology conducted at the ESEB 2021 Online Satellite Symposium: Molecular evolution of the vertebrate immune system, from the lab to natural populations.es_ES
dc.description.sponsorshipBiotechnology and Biological Sciences Research Counciles_ES
dc.description.sponsorshipGrant/Award Number: BB/K004468/1, BB/M011224/1, BB/ N023803/1 and BB/V000756/1es_ES
dc.description.sponsorshipDepartment for Environment, Food and Rural Affairses_ES
dc.description.sponsorshipUK Government, Grant/ Award Number: OD0221es_ES
dc.description.sponsorshipDeutsche Forschungsgemeinschaft, Grant/ Award Number: 437857095es_ES
dc.description.sponsorshipGrantová Agentura České Republiky, Grant/Award Number: 19-20152Yes_ES
dc.description.sponsorshipGrantová Agentura, Univerzita Karlova, Grant/Award Number: 646119es_ES
dc.description.sponsorshipH2020 European Research Council, Grant/Award Number: ERC-2019- StG- 853272- PALAEOFARMes_ES
dc.description.sponsorshipUniversity of Oxford, Grant/Award Number: 0005172; Ministerstvo Školství, Mládeže a Tělovýchovyes_ES
dc.description.sponsorshipGrant/Award Number: SVV 260684/2023; Ministerstvo Zemědělství, Grant/Award Number: MZE-RO0723es_ES
dc.description.sponsorshipNational Institutes of Health, Grant/Award Number: 1R01AI123659-01A1; Univerzita Karlova v Prazees_ES
dc.description.sponsorshipGrant/Award Number: START/SCI/113 with reg. no. CZ.02.2.69/0.0/0.0/19_; Vetenskapsrådet, Grant/Award Number: 2020-04285es_ES
dc.rightsAtribución 4.0 Internacional*
dc.subjectAdaptive immunityes_ES
dc.subjectEvolutionary immunologyes_ES
dc.subjectInnate immunityes_ES
dc.subjectMolecular evolutiones_ES
dc.subjectVertebrates es_ES
dc.titleUnderstanding the evolution of immune genes in jawed vertebrateses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/ 853272es_ES
dc.identifier.doiDOI: 10.1111/jeb.14181

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Atribución 4.0 Internacional
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