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Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent advances in cancer treatment
dc.contributor.author | Graván, Pablo | |
dc.contributor.author | Aguilera Garrido, Aixa María | |
dc.contributor.author | Marchal Corrales, Juan Antonio | |
dc.contributor.author | Navarro Marchal, Saul Abenhamar | |
dc.contributor.author | Galisteo González, Francisco | |
dc.date.accessioned | 2023-06-21T07:39:10Z | |
dc.date.available | 2023-06-21T07:39:10Z | |
dc.date.issued | 2023-03-09 | |
dc.identifier.citation | P. Graván et al. Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent advances in cancer treatment. Advances in Colloid and Interface Science 314 (2023) 102871[https://doi.org/10.1016/j.cis.2023.102871] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/82668 | |
dc.description.abstract | Nanotechnological drug delivery platforms represent a new paradigm for cancer therapeutics as they improve the pharmacokinetic profile and distribution of chemotherapeutic agents over conventional formulations. Among nanoparticles, lipid-based nanoplatforms possessing a lipid core, that is, lipid-core nanoparticles (LCNPs), have gained increasing interest due to lipid properties such as high solubilizing potential, versatility, biocompatibility, and biodegradability. However, due to the wide spectrum of morphologies and types of LCNPs, there is a lack of consensus regarding their terminology and classification. According to the current state-of-the-art in this critical review, LCNPs are defined and classified based on the state of their lipidic components in liquid lipid nanoparticles (LLNs). These include lipid nanoemulsions (LNEs) and lipid nanocapsules (LNCs), solid lipid nanoparticles (SLNs) and nanostructured lipid nanocarriers (NLCs). In addition, we present a comprehensive and comparative description of the methods employed for their preparation, routes of administration and the fundamental role of physicochemical properties of LCNPs for efficient antitumoral drug-delivery application. Market available LCNPs, clinical trials and preclinical in vivo studies of promising LCNPs as potential treatments for different cancer pathologies are summarized. | es_ES |
dc.description.sponsorship | MCIN/AEI FPU18/05336 | es_ES |
dc.description.sponsorship | European Social Fund (ESF) | es_ES |
dc.description.sponsorship | Ph.D. program of Biomedicine of the University of Granada | es_ES |
dc.description.sponsorship | MCIN/AEI/FEDER "Una manera de hacer Europa" RTI2018.101309B-C21 RTI2018.101309B-C22 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Lipid nanoemulsions | es_ES |
dc.subject | Lipid nanocapsules | es_ES |
dc.subject | Solid lipid nanoparticles | es_ES |
dc.subject | Nanostructured lipid nanocarriers | es_ES |
dc.subject | Cáncer | es_ES |
dc.subject | Preparation methods | es_ES |
dc.subject | Routes of administration | es_ES |
dc.title | Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent advances in cancer treatment | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1016/j.cis.2023.102871 | |
dc.type.hasVersion | VoR | es_ES |