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Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status
| dc.contributor.author | Khoury, Nadine | |
| dc.contributor.author | Bueno Cavanillas, Aurora | |
| dc.contributor.author | Salcedo Bellido, Inmaculada | |
| dc.date.accessioned | 2023-06-12T07:33:32Z | |
| dc.date.available | 2023-06-12T07:33:32Z | |
| dc.date.issued | 2023-03-25 | |
| dc.identifier.uri | https://hdl.handle.net/10481/82325 | |
| dc.description.abstract | dibenzop- furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55–75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/ obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results. | es_ES |
| dc.description.sponsorship | nstituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund PI16/01120 PI17/00764 PI17/01183 PI17/00855 PI17/01347 PI17/00525 PI17/01827 PI17/00532 PI17/00215 PI17/01441 PI17/00508 PI17/01732 PI17/00926 PI19/00957 PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017 PI19/01226 PI19/00781 PI19/01560 PI19/01332 PI20/01802 PI20/00138 PI20/01532 PI20/00456 PI20/00339 PI20/00557 PI20/00886 PI20/01158 | es_ES |
| dc.description.sponsorship | CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) | es_ES |
| dc.description.sponsorship | Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant | es_ES |
| dc.description.sponsorship | European Research Council (ERC) European Commission 340918 | es_ES |
| dc.description.sponsorship | La Caixa Foundation 2013ACUP00194 | es_ES |
| dc.description.sponsorship | Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018 | es_ES |
| dc.description.sponsorship | Center for Forestry Research & Experimentation (CIEF) PROMETEO/21/2021 | es_ES |
| dc.description.sponsorship | MICIN/AEI/FEDER, UE CEX2021-001234-M | es_ES |
| dc.description.sponsorship | SEMERGEN grant | es_ES |
| dc.description.sponsorship | ICREA under the ICREA Academia program | es_ES |
| dc.description.sponsorship | Agencia de Gestio d'Ajuts Universitaris de Recerca (AGAUR FI) 2021FI_B 00145 | es_ES |
| dc.language.iso | eng | es_ES |
| dc.rights | Atribución 4.0 Internacional | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | Polychlorinated dibenzo-p-furans (PCDD/F) | es_ES |
| dc.subject | Adiposity | es_ES |
| dc.subject | Obesity | es_ES |
| dc.subject | Abdominal obesity | es_ES |
| dc.subject | Endocrine disrupting chemicals | es_ES |
| dc.title | Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status | es_ES |
| dc.type | journal article | es_ES |
| dc.relation.projectID | info:eu-repo/grantAgreement/EC/340918 | es_ES |
| dc.rights.accessRights | open access | es_ES |
| dc.identifier.doi | 10.1016/j.envres.2023.115697 | |
| dc.type.hasVersion | VoR | es_ES |
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