Systematic Review and Meta-Analyses of Aminopeptidases as Prognostic Biomarkers in Amyotrophic Lateral Sclerosis
Metadatos
Afficher la notice complèteAuteur
Teruel Peña, Bárbara; Gómez Urquiza, Jose Luis; Suleiman Martos, Nora; Prieto, Isabel; Ramírez Sánchez, Manuel; Domínguez Vías, GermanEditorial
MDPI
Materia
Amyotrophic lateral sclerosis Aminopeptidase Biomarker
Date
2023-04-12Referencia bibliográfica
Teruel-Peña, B.; Gómez-Urquiza, J.L.; Suleiman-Martos, N.; Prieto, I.; García-Cózar, F.J.; Ramírez-Sánchez, M.; Fernández-Martos, C.; Domínguez-Vías, G. Systematic Review and Meta-Analyses of Aminopeptidases as Prognostic Biomarkers in Amyotrophic Lateral Sclerosis. Int. J. Mol. Sci. 2023, 24, 7169. https://doi.org/10.3390/ijms24087169
Patrocinador
PPJIA2022.09, “Plan Propio de Investigación y Transferencia de la Universidad de Granada; 2022: Programa 20; Proyectos de Investigación Precompetitivos para Jóvenes Investigadores. Modalidad 20.a; Proyectos para jóvenes doctores” corresponding to the year 2022 with reference no. 11 (File no. 1586950); University of Granada (Spain). Accepted: 23 December 2022Résumé
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons in the spinal cord, brain stem, and cerebral cortex. Biomarkers
for ALS are essential for disease detection and to provide information on potential therapeutic
targets. Aminopeptidases catalyze the cleavage of amino acids from the amino terminus of protein or
substrates such as neuropeptides. Since certain aminopeptidases are known to increase the risk of
neurodegeneration, such mechanisms may reveal new targets to determine their association with
ALS risk and their interest as a diagnostic biomarker. The authors performed a systematic review and
meta-analyses of genome-wide association studies (GWASs) to identify reported aminopeptidases
genetic loci associated with the risk of ALS. PubMed, Scopus, CINAHL, ISI Web of Science, ProQuest,
LILACS, and Cochrane databases were searched to retrieve eligible studies in English or Spanish,
published up to 27 January 2023. A total of 16 studies were included in this systematic review, where
a series of aminopeptidases could be related to ALS and could be promising biomarkers (DPP1,
DPP2, DPP4, LeuAP, pGluAP, and PSA/NPEPPS). The literature reported the association of singlenucleotide
polymorphisms (SNPs: rs10260404 and rs17174381) with the risk of ALS. The genetic
variation rs10260404 in the DPP6 gene was identified to be highly associated with ALS susceptibility,
but meta-analyses of genotypes in five studies in a matched cohort of different ancestry (1873 cases
and 1861 control subjects) showed no ALS risk association. Meta-analyses of eight studies for minor
allele frequency (MAF) also found no ALS association for the “C” allele. The systematic review
identified aminopeptidases as possible biomarkers. However, the meta-analyses for rs1060404 of
DPP6 do not show a risk associated with ALS.