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Spherulitic Crystal Growth Drives Mineral Deposition Patterns in Collagen-Based Materials
dc.contributor.author | Macías Sánchez, Elena | |
dc.contributor.author | Tarakina, Nadezda V | |
dc.contributor.author | Ivanov, Danail | |
dc.contributor.author | Blouin, Stéphane | |
dc.contributor.author | Berzlanovich, Andrea M | |
dc.contributor.author | Fratzl, Peter | |
dc.date.accessioned | 2023-06-05T09:17:04Z | |
dc.date.available | 2023-06-05T09:17:04Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Macías‐Sánchez, E., Tarakina, N.V., Ivanov, D., Blouin, S., Berzlanovich, A.M. and Fratzl, P., 2022. Spherulitic Crystal Growth Drives Mineral Deposition Patterns in Collagen‐Based Materials. Advanced Functional Materials, p.2200504. [https://doi.org/10.1002/adfm.202200504] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/82223 | |
dc.description.abstract | The formation of the hard tissues that provide support and mobility to organisms is achieved through the interplay of inorganic crystals and an organic framework composed of collagen and a small percentage of non-collagenous proteins. Despite their clinical relevance, the mechanisms governing mineralization of the extracellular matrix are still poorly understood. By using 3D electron tomography and high-resolution electron microscopy imaging and spectroscopy, it has been demonstrated that mineralization proceeds through a spherulitic-like crystal growth process. First, aggregates of disordered crystals form in the interfibrillar spaces, which lead to the mineralization of adjacent fibrils. Mineral propagates steadily through the inter- and intrafibrillar spaces of the collagen structure forming layered spherulites that grow to confluence. The structure of the collagen fibrils serves as a protein scaffold to guide the formation of a myriad of platelet-shaped crystallites that make up each of these spherulites. At their periphery, nanosized unmineralized areas remain, leading to the formation of the characteristic lacy pattern observed in the transversal cross-section of mature calcified tissues. This study provides fundamental insights into the bone formation process and represents a potential strategy for complex materials design | es_ES |
dc.description.sponsorship | Projekt DEAL | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wyley | es_ES |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | 3D electron microscopy | es_ES |
dc.subject | Bone mineralization | es_ES |
dc.subject | Collagen mineralization | es_ES |
dc.subject | Energy dispersive X-ray spectroscopy | es_ES |
dc.subject | Transmission electron microscopy | es_ES |
dc.title | Spherulitic Crystal Growth Drives Mineral Deposition Patterns in Collagen-Based Materials | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1002/adfm.202200504 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |