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Serum nuclear magnetic resonance metabolomics analysis of human metastatic colorectal cancer: Biomarkers and pathway analysis
dc.contributor.author | Tristán, Ana Isabel | |
dc.contributor.author | Caba Pérez, Octavio | |
dc.contributor.author | Jiménez Luna, Cristina | |
dc.contributor.author | Melguizo Alonso, Consolación | |
dc.contributor.author | Prados Salazar, José Carlos | |
dc.date.accessioned | 2023-05-30T12:27:11Z | |
dc.date.available | 2023-05-30T12:27:11Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Tristán AI, González-Flores E, Salmer on AM, et al. Serum nuclear magnetic resonance metabolomics analysis of human metastatic colorectal cancer: Biomarkers and pathway analysis. NMR in Biomedicine. 2023;e4935. [doi:10.1002/nbm.4935] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/82033 | |
dc.description | Junta de Andalucía, Grant/Award Numbers: 102C2000004, UAL2020-AGR-B1781, P20_01041; Gobierno de España, Grant/Award Numbers: PDC2021– 121248-I00, PLEC2021–007774; Instituto de Salud Carlos III (ISCIII), Grant/Award Number: PI19/01478; CTS-107 and FQM-376 groups | es_ES |
dc.description.abstract | We describe the use of nuclear magnetic resonance metabolomics to analyze blood serum samples from healthy individuals (n = 26) and those with metastatic colorectal cancer (CRC; n = 57). The assessment, employing both linear and nonlinear multivari- ate data analysis techniques, revealed specific metabolite changes associated with metastatic CRC, including increased levels of lactate, glutamate, and pyruvate, and decreased levels of certain amino acids and total fatty acids. Biomarker ratios such as glutamate-to-glutamine and pyruvate-to-alanine were also found to be related to CRC. The study also found that glutamate was linked to progression-free survival and that both glutamate and 3-hydroxybutyrate were risk factors for metastatic CRC. Additionally, gas chromatography coupled to flame-ionization detection was utilized to analyze the fatty acid profile and pathway analysis was performed on the profiled metabolites to understand the metabolic processes involved in CRC. A correlation was also found between the presence of certain metabolites in the blood of CRC patients and certain clinical features. | es_ES |
dc.description.sponsorship | Junta de Andalucia 102C2000004, UAL2020-AGR-B1781, P20_01041 | es_ES |
dc.description.sponsorship | Gobierno de España MCIN/AEI/10.13039/501100011033/Unión Europea “Next GenerationEU”/PRTR (PDC2021–121248-I00 and PLEC2021–007774) | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III (ISCIII) (PI19/01478) (FEDER) | es_ES |
dc.description.sponsorship | CTS-107 | es_ES |
dc.description.sponsorship | FQM-376 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Serum nuclear magnetic resonance metabolomics analysis of human metastatic colorectal cancer: Biomarkers and pathway analysis | es_ES |
dc.type | journal article | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/Next GenerationEU/PRTR (PDC2021–121248-I00 and PLEC2021–007774) | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1002/nbm.4935 | |
dc.type.hasVersion | VoR | es_ES |