Effect of exercise on bone health in children and adolescents with cancer during and after oncological treatment: A systematic review and meta-analysis
Metadatos
Mostrar el registro completo del ítemAutor
Mármol Pérez, Andrés; Ubago Guisado, Esther; Rodríguez Solana, Andrea; Gil Cosano, José Juan; Ruiz, Jonatan R.; Gracia Marco, Luis AndrésEditorial
Frontiers
Materia
Bone mineral Density Dual-energy x-ray absorptiometry Impact-loading exercise Paediatrics Physical Activity
Fecha
2023-03-14Referencia bibliográfica
Marmol-Perez A, Ubago-Guisado E, Rodriguez-Solana A, Gil-Cosano JJ, Martinez-Vizcaino V, Cavero-Redondo I, Ruiz JR and Gracia-Marco L (2023), Effect of exercise on bone health in children and adolescents with cancer during and after oncological treatment: A systematic review and meta-analysis. Front. Physiol. 14:1088740. [doi: 10.3389/fphys.2023.1088740]
Patrocinador
Spanish Ministry of Science and Innovation (ref: PID2020-117302RA-I00; La Caixa Foundation (ref: LCF/BQ/PR19/11700007); the University of Granada Plan Propio de Investigación 2021-Excellence actions: Unit of Excellence on Exercise, Nutrition and Health (UCEENS); CIBEROBN, Centro de Investigación Biomédica en Red (CB22/03/ 00058; Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea – European Regional Development Fund. AM-P is recipient of a predoctoral fellowship (FPU20/05530) by the Spanish Ministry of Education, Culture and Sport. EU-G is supported by the Maria Zambrano fellowship by the Ministerio de Universidades y la Unión Europea—NextGenerationEU.Resumen
Background: Although regular physical activity and exercise programs might
improve bone health caused by oncological treatment and the disease itself, it
remains unknown the pooled effect of exercise interventions following frequency,
intensity, time and type prescriptions.
Objective: This systematic review and meta-analysis aimed to synthesise evidence
regarding the effectiveness of exercise interventions on bone health in children
and adolescents with cancer during and after oncological treatment.
Methods: A systematic search was conducted in the MEDLINE (via PubMed), Web
of Science and Scopus databases from November 2021 to January 2022.
Randomised controlled trials (RCTs) and non-RCTs reporting pre-post changes
of the effectiveness of exercise interventions on DXA-measured bone parameters
in young population (1–19 years) during or after oncological treatment were
included. Pooled (ESs) and 95% confidence intervals (95%CIs) were calculated.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses
guidelines were followed.
Results: A total of eight trials with 341 participants were included. The metaanalyses
did not reveal a statistically significant increase in whole body areal bone
mineral density (ES = 0.10; 95%CI: −0.14, 0.34), lumbar spine (ES = 0.03; 95%CI:
−0.21, 0.26) or femoral neck (ES = 0.10; 95%CI: −0.37, 0.56). Similarly, during the
oncological treatment phase the ES was 0.04 (95%CI: −0.17, 0.25) and after the ES
was 0.07 (95%CI: −0.20, 0.33).
Conclusion: To date, exercise interventions have been inappropriate and
therefore, ineffective to illustrate any beneficial effect on bone health in
children and adolescents with cancer during and after oncological treatment.