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Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro-oxidant activity
dc.contributor.author | Pérez Garrido, Laura | |
dc.contributor.author | Ortega Muñoz, Mariano | |
dc.contributor.author | Hernández Mateo, Fernando | |
dc.contributor.author | López Jaramillo, Francisco Javier | |
dc.contributor.author | Santoyo González, Francisco | |
dc.date.accessioned | 2023-05-17T07:46:43Z | |
dc.date.available | 2023-05-17T07:46:43Z | |
dc.date.issued | 2023-03-16 | |
dc.identifier.citation | Perez-Garrido, L., Ortega-Muñoz, M., Hernandez-Mateo, F. et al. Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro-oxidant activity. Nano Res. (2023). [https://doi.org/10.1007/s12274-023-5442-3] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/81599 | |
dc.description.abstract | Selenium (Se) has been defined as the “Janus element”, with one face showing antioxidant activity and the other pro-oxidant activity. The biological effect of Se depends on both dose and speciation. Se nanoparticles are attracting major interest, although their large-scale preparation for biomedical applications is not trivial. We hypothesize that acid anhydride-coated carbon dots (AACD) are an attractive platform for preparing nanoparticles containing chemically defined Se. The reaction of AA-CD with 3- selenocyanatopropan-1-amine yields carbon dots bearing selenocyanate and carboxylate groups (CD-SeCN) that allow for tuning the hydrosolubility. CD-SeCN has a Se content of 0.36 μmol per mg of nanoparticles, and they show the typical photoluminescence of carbon dots. The selenocyanate groups (SeCN) exhibited glutathione peroxidase-like activity and cytotoxicity. Data show that antioxidant behavior differs between normal and tumor cells, and the evaluation on HEK293 and A549 cells reveals that the toxicity of CD-SeCN depends on dose, time, and intracellular glutathione (GSH) content. The toxicity of CD-SeCN decreases with the time of incubation and the cell death mechanism switches from necrosis to apoptosis, indicating that CD-SeCN is neutralized. Additionally, high levels of intracellular GSH exert a protective effect. These results support a pharmacological potential in cancers with low levels of intracellular GSH. The use of AA-CD as nanoplatforms is a general strategy that paves the way for the engineering of advanced nanosystems | es_ES |
dc.description.sponsorship | Spanish institution Ministerio de Ciencia, Innovacion y Universidades (No. CTQ2017- 86125-P) | es_ES |
dc.description.sponsorship | Unit of Excellence in Chemistry Applied to Biomedicine and the Environment | es_ES |
dc.description.sponsorship | Centro de Instrumentacion Cientifica (Universidad de Granada) | es_ES |
dc.description.sponsorship | Universidad de Granada/CBUA | es_ES |
dc.description.sponsorship | Springer Nature | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Selenium nanoparticles | es_ES |
dc.subject | Carbon dots | es_ES |
dc.subject | Glutathione peroxidase-like activity | es_ES |
dc.subject | Janus element | es_ES |
dc.subject | Nanomedicine | es_ES |
dc.title | Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro-oxidant activity | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1007/s12274-023-5442-3 | |
dc.type.hasVersion | VoR | es_ES |