Lifestyle physical activity and rapid-rate non sustained ventricular tachycardia in arrhythmogenic cardiomyopathy
Metadatos
Mostrar el registro completo del ítemEditorial
BMJ Group
Fecha
2023-02-27Referencia bibliográfica
Ramos-Maqueda J, Migueles JH, Molina Jiménez M, et al. Heart Epub ahead of print: [please include Day Month Year]. [doi:10.1136/ heartjnl-2022-32182]
Patrocinador
Junta de Andalucia PIER-0231-2019; Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte) 2021-00036Resumen
Objective To investigate the association of
accelerometer-measured lifestyle physical activity with
rapid-rate non-sustained ventricular tachycardias (RR NSVTs) in patients with arrhythmogenic cardiomyopathy
(AC).
Methods This multicentre, observational study enrolled
72 patients with AC, including right, left and biventricular
forms of the disease, with underlying desmosomal and
non-desmosomal mutations. Lifestyle physical activity,
objectively monitored with accelerometers (ie, movement
sensors) and RR-NSVT, identified as >188 bpm and >18
beats from a textile Holter ECG for 30 days.
Results Sixty-three patients with AC (38±17.6 years,
57% men) were included. A total of 17 patients
experienced ≥1 RR-NSVTs, and a total of 35 events
were recorded. The odds of occurrence of ≥1 RR-NSVT
during the recording did not increase as a function of
either total physical activity (OR 0.95, 95% CI (CI95%)
0.68 to 1.30 for 60 min increase) or moderate-to vigorous activities (OR 0.89, CI95% 0.71 to 1.08 for 5 min
increase). Participants presenting RR-NSVTs during the
recording (n=17) did not present greater odds of RR NSVT in the days with more time either in total physical
activity (OR 1.05, CI95% 0.84 to 1.29 for additional 60
min) or moderate-to-vigorous activities (OR 1.05, CI95%
0.97 to 1.12 for additional 5 min). Physical activity levels
were neither different between the patients with and
without RR-NSVTs during the recording period nor in the
days of occurrence of RR-NSVT compared with the rest
of the days. Finally, 4 of the 35 RR-NSVTs recorded in
the 30 days occurred during physical activity (3 during
moderate-to-vigorous intensity and 1 during light intensity activities).
Conclusions These findings suggest that lifestyle
physical activity is not associated with RR-NSVTs in
patients with AC.