Mostrar el registro sencillo del ítem
Estradiol and Estrone Have Different Biological Functions to Induce NF-kappa B-Driven Inflammation, EMT and Stemness in ER plus Cancer Cells
dc.contributor.author | Díaz Ruano, Ana Belén | |
dc.contributor.author | Martínez Alarcón, Nuria | |
dc.contributor.author | Perán, Macarena | |
dc.contributor.author | Benabdellah, Karim | |
dc.contributor.author | García Martínez, María de los Ángeles | |
dc.contributor.author | Preda, Ovidiu | |
dc.contributor.author | Ramírez Tortosa, César Luis | |
dc.contributor.author | González hernández, Andrea | |
dc.contributor.author | Marchal Corrales, Juan Antonio | |
dc.contributor.author | Picón Ruiz, Manuel | |
dc.date.accessioned | 2023-03-06T08:34:41Z | |
dc.date.available | 2023-03-06T08:34:41Z | |
dc.date.issued | 2023-01-07 | |
dc.identifier.citation | Diaz-Ruano, A.B... [et al.]. Estradiol and Estrone Have Different Biological Functions to Induce NF- B-Driven Inflammation, EMT and Stemness in ER+ Cancer Cells. Int. J. Mol. Sci. 2023, 24, 1221. [https://doi.org/10.3390/ijms24021221] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/80411 | |
dc.description.abstract | In general, the risk of being diagnosed with cancer increases with age; however, the development of estrogen-receptor-positive (ER+) cancer types in women are more closely related to menopausal status than age. In fact, the general risk factors for cancer development, such as obesity-induced inflammation, show differences in their association with ER+ cancer risk in pre- and postmenopausal women. Here, we tested the role of the principal estrogens in the bloodstream before and after menopause, estradiol (E2) and estrone (E1), respectively, on inflammation, epithelial-tomesenchymal transition (EMT) and cancer stem cell enrichment in the human ER+ cervical cancer cell line HeLa. Our results demonstrate that E1, contrary to E2, is pro-inflammatory, increases embryonic stem-transcription factors (ES-TFs) expression and induces EMT in ER+ HeLa cells. Moreover, we observed that high intratumoural expression levels of 17 -Hydroxysteroid dehydrogenase (HSD17B) isoforms involved in E1 synthesis is a poor prognosis factor, while overexpression of E2-synthetizing HSD17B isoforms is associated with a better outcome, for patients diagnosed with ER+ ovarian and uterine corpus carcinomas. This work demonstrates that E1 and E2 have different biological functions in ER+ gynaecologic cancers. These results open a new line of research in the study of ER+ cancer subtypes, highlighting the potential key oncogenic role of E1 and HSD17B E1-synthesizing enzymes in the development and progression of these diseases. | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III PIE16-00045 | es_ES |
dc.description.sponsorship | Ministry of Health and Family of the Junta de Andalucia | es_ES |
dc.description.sponsorship | European Commission PEMP-0205-2020 | es_ES |
dc.description.sponsorship | Spanish Ministry of Science, Innovation and Universities (MICIN) MSCA-IF-2018 845104 | es_ES |
dc.description.sponsorship | European Commission European Commission Joint Research Centre PID2020-119502RJ-I00 | es_ES |
dc.description.sponsorship | State Research Agency from the Spanish Ministry of Science and Innovation (MICIN/AEI) CMC-CTS963 0006/2018 | es_ES |
dc.description.sponsorship | Chair "Doctors Galera-Requena in cancer stem cell research" PECART-0027-2020 regional Ministry of Health | es_ES |
dc.description.sponsorship | Consejeria de Salud y Familias RTI2018-101309-B-C22 RYC2020-030808-I | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | ER+ cancer | es_ES |
dc.subject | Estradiol | es_ES |
dc.subject | Estrone | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | NF-KB | es_ES |
dc.subject | HSD17B | es_ES |
dc.title | Estradiol and Estrone Have Different Biological Functions to Induce NF-kappa B-Driven Inflammation, EMT and Stemness in ER plus Cancer Cells | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/ijms24021221 | |
dc.type.hasVersion | VoR | es_ES |