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dc.contributor.authorRuiz Ojeda, Francisco Javier 
dc.contributor.authorAnguita Ruiz, Augusto
dc.contributor.authorCruz Rico, María
dc.contributor.authorGil Hernández, Ángel 
dc.contributor.authorAguilera García, Concepción María 
dc.date.accessioned2023-02-10T12:28:56Z
dc.date.available2023-02-10T12:28:56Z
dc.date.issued2023-01-03
dc.identifier.citationRuiz-Ojeda, F.J... [et al.]. Serum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys. World J Pediatr (2023). [https://doi.org/10.1007/s12519-022-00665-8]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/79826
dc.description.abstractObjectives To evaluate whether there is an association between the serum levels of the novel insulin-like adipokine isthmin- 1 (ISM1) and obesity-related phenotypes in a population of Spanish children and to investigate the plausible molecular alterations behind the alteration of the serum levels of this protein in children with obesity. Methods The study population is a sub-cohort of the PUBMEP research project, consisting of a cross-sectional population of 119 pubertal children with overweight (17 boys, 19 girls), obesity (20 boys, 25 girls), and normal weight (17 boys, 21 girls). All subjects were classified into experimental groups according to their sex, obesity, and insulin resistance (IR) status. They were counted anthropometry, glucose and lipid metabolism, inflammation and cardiovascular biomarkers as well as isthmin-1 (ISM1) serum levels. This population was intended as a discovery population to elucidate the relationship between obesity and ISM1 levels in children. Furthermore, the study population had blood whole-genome DNA methylation examined, allowing deepening into the obesity–ISM1 molecular relationship. Results Higher serum ISM1 levels were observed in boys with obesity than in normal weight (P = 0.004) and overweight (P = 0.007) boys. ISM1 serum levels were positively associated with body mass index (BMI) Z-score (P = 0.005) and fat mass (P = 0.058) and negatively associated with myeloperoxidase (MPO) (P = 0.043) in boys. Although we did not find associations between ISM1 serum levels and metabolic outcomes in girls, which may indicate a putative sexual dimorphism, fat mass was positively associated in all children, including boys and girls (P = 0.011). DNA methylation levels in two-enhancer-related CpG sites of ISM1 (cg03304641 and cg14269097) were associated with serum levels of ISM1 in children. Conclusions ISM1 is associated with obesity in boys at the pubertal stage, elucidating how this protein might be of special relevance as a new biomarker of obesity in children. Further studies including a longitudinal design during puberty are needed.es_ES
dc.description.sponsorshipUniversidad de Granada/CBUAes_ES
dc.description.sponsorshipPlan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) PI051968 PI1102042 PI1600871es_ES
dc.description.sponsorshipRedes tematicas de Investigacion cooperativa RETIC Red SAMID RD12/0026/0015es_ES
dc.description.sponsorshipMapfre Foundationes_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectChildrenes_ES
dc.subjectEpigeneticses_ES
dc.subjectIsthmin-1es_ES
dc.subjectObesity es_ES
dc.subjectPuberty es_ES
dc.titleSerum levels of the novel adipokine isthmin‑1 are associated with obesity in pubertal boyses_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1007/s12519-022-00665-8
dc.type.hasVersionVoRes_ES


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