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A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
dc.contributor.author | Fernández Jiménez, Nora | |
dc.contributor.author | Martorell Marugán, Jordi | |
dc.contributor.author | Carmona Sáez, Pedro | |
dc.contributor.author | Fernández Cabrera, Mariana Fátima | |
dc.contributor.author | Gómez Martín, Antonio | |
dc.contributor.author | González Alzaga, Beatriz | |
dc.contributor.author | Lacasaña, Marina | |
dc.date.accessioned | 2022-12-22T08:11:33Z | |
dc.date.available | 2022-12-22T08:11:33Z | |
dc.date.issued | 2022-11-30 | |
dc.identifier.citation | Fernandez-Jimenez, N... [et al.]. A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health. Commun Biol 5, 1313 (2022). [https://doi.org/10.1038/s42003-022-04267-y] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/78604 | |
dc.description.abstract | Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ in fetal development and has been proposed to act as a mediator between the mother and different health outcomes in children. The overall aim of the present work is to investigate the association of ppBMI with epigenomewide placental DNA methylation (DNAm) in 10 studies from the PACE consortium, amounting to 2631 mother-child pairs. We identify 27 CpG sites at which we observe placental DNAm variations of up to 2.0% per 10 ppBMI-unit. The CpGs that are differentially methylated in placenta do not overlap with CpGs identified in previous studies in cord blood DNAm related to ppBMI. Many of the identified CpGs are located in open sea regions, are often close to obesity-related genes such as GPX1 and LGR4 and altogether, are enriched in cancer and oxidative stress pathways. Our findings suggest that placental DNAm could be one of the mechanisms by which maternal obesity is associated with metabolic health outcomes in newborns and children, although further studies will be needed in order to corroborate these findings. | es_ES |
dc.description.sponsorship | French Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences de l'Univers (INSU) | es_ES |
dc.description.sponsorship | Swiss National Science Foundation (SNSF) | es_ES |
dc.description.sponsorship | European Commission | es_ES |
dc.description.sponsorship | Ministry of Science and Innovation, Spain (MICINN) | es_ES |
dc.description.sponsorship | Spanish Government FJC2018-036729 | es_ES |
dc.description.sponsorship | European Development Fund | es_ES |
dc.description.sponsorship | European Social Fund (ESF) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1038/s42003-022-04267-y | |
dc.type.hasVersion | VoR | es_ES |