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Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility

dc.contributor.authorCerván Martín, Miriam 
dc.contributor.authorBossini Castillo, Lara María 
dc.contributor.authorGonzález Muñoz, Sara
dc.contributor.authorGuzmán Jiménez, Andrea
dc.contributor.authorBurgos Poyatos, Miguel 
dc.contributor.authorJiménez Medina, Rafael 
dc.contributor.authorPalomino Morales, Rogelio Jesús 
dc.contributor.authorCarmona López, Francisco David 
dc.date.accessioned2022-11-30T12:11:01Z
dc.date.available2022-11-30T12:11:01Z
dc.date.issued2022-11-10
dc.identifier.citationCerván-Martín, M., Tüttelmann, F., Lopes, A.M. et al. Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility. Commun Biol 5, 1220 (2022). [https://doi.org/10.1038/s42003-022-04192-0]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/78210
dc.descriptionAcknowledgements We thank the National DNA Bank Carlos III (University of Salamanca, Spain) for supplying part of the control DNA samples from Spain and all the participants for their essential collaboration. This work was supported by the Spanish Ministry of Science through the Spanish National Plan for Scientific and Technical Research and Innovation (refs. SAF2016-78722-R and PID2020-120157RB-I00), the Andalusian Plan for Research and Innovation (PAIDI 2020) (ref. PY20_00212), and the R+D+i Projects of the FEDER Operational Programme 2020 (ref. B-CTS-584-UGR20). F.D.C. was supported by the “Ramón y Cajal” programme (ref. RYC-2014-16458), and L.B.C. was supported by the Spanish Ministry of Economy and Competitiveness through the “Juan de la Cierva Incorporación” programme (ref. IJC2018-038026-I, funded by MCIN/AEI /10.13039/ 501100011033), all of them including FEDER funds. A.G.J. was funded by MCIN/AEI /10.13039/501100011033 and FSE “El FSE invierte en tu futuro” (ref. FPU20/02926). IPATIMUP integrates the i3S Research Unit, which is partially supported by the Portuguese Foundation for Science and Technology (FCT), financed by the European Social Funds (COMPETE-FEDER) and National Funds (projects PEstC/SAU/LA0003/2013 and POCI-01-0145-FEDER-007274). A.M.L. is funded by the Portuguese Government through FCT (IF/01262/2014). P.I.M. is supported by the FCT post-doctoral fellowship (SFRH/BPD/120777/2016), financed from the Portuguese State Budget of the Ministry for Science, Technology and High Education and from the European Social Fund, available through the Programa Operacional do Capital Humano. ToxOmics—Centre for Toxicogenomics and Human Health, Genetics, Oncology and Human Toxicology, Nova Medical School, Lisbon, is also partially supported by FCT (Projects: UID/BIM/00009/ 2013 and UIDB/UIDP/00009/2020). SLarriba received support from “Instituto de Salud Carlos III” (grant DTS18/00101], co-funded by FEDER funds/European Regional Development Fund (ERDF)—a way to build Europe), and from “Generalitat de Catalunya” (grant 2017SGR191). SLarriba is sponsored by the “Researchers Consolidation Programme” from the SNS-Departament de Salut Generalitat de Catalunya (Exp. CES09/ 020). The German cohort was recruited within the Male Reproductive Genomics (MERGE) study and supported by the German Research Foundation Clinical Research Unit ‘Male Germ Cells’ (DFG CRU326, grants to F.T. and J.G.). This article is related to the Ph.D. Doctoral Thesis of Miriam Cerván-Martín (grant ref. BES-2017-081222 funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”).es_ES
dc.description.abstractWe conducted a genome-wide association study in a large population of infertile men due to unexplained spermatogenic failure (SPGF). More than seven million genetic variants were analysed in 1,274 SPGF cases and 1,951 unaffected controls from two independent European cohorts. Two genomic regions were associated with the most severe histological pattern of SPGF, defined by Sertoli cell-only (SCO) phenotype, namely the MHC class II gene HLA-DRB1 (rs1136759, P = 1.32E-08, OR = 1.80) and an upstream locus of VRK1 (rs115054029, P = 4.24E-08, OR = 3.14), which encodes a protein kinase involved in the regulation of spermatogenesis. The SCO-associated rs1136759 allele (G) determines a serine in the position 13 of the HLA-DRβ1 molecule located in the antigen-binding pocket. Overall, our data support the notion of unexplained SPGF as a complex trait influenced by common variation in the genome, with the SCO phenotype likely representing an immune-mediated condition.es_ES
dc.description.sponsorshipAndalusian Plan for Research and Innovationes_ES
dc.description.sponsorshipJuan de la Cierva Incorporación IJC2018-038026-Ies_ES
dc.description.sponsorshipMinistry for Science, Technology and High Educationes_ES
dc.description.sponsorshipBES-2017-081222, MCIN/AEI/10.13039/501100011033es_ES
dc.description.sponsorshipNational Funds IF/01262/2014, PEstC/SAU/LA0003/2013, POCI-01-0145-FEDER-007274, SFRH/BPD/120777/2016es_ES
dc.description.sponsorshipPAIDI 2020 PY20_00212es_ES
dc.description.sponsorshipR+D+i Projects B-CTS-584-UGR20, RYC-2014-16458es_ES
dc.description.sponsorshipFaculty of Science and Engineering, University of Manchester FPU20/02926es_ES
dc.description.sponsorshipDeutsche Forschungsgemeinschaft DFG CRU326es_ES
dc.description.sponsorshipFundação para a Ciência e a Tecnologiaes_ES
dc.description.sponsorshipGeneralitat de Catalunya 2017SGR191es_ES
dc.description.sponsorshipMinisterio de Economía y Competitividades_ES
dc.description.sponsorshipInstituto de Salud Carlos III DTS18/00101es_ES
dc.description.sponsorshipMinisterio de Ciencia e Innovaciónes_ES
dc.description.sponsorshipEuropean Social Fund UIDB/UIDP/00009/2020es_ES
dc.description.sponsorshipEuropean Regional Development Fundes_ES
dc.description.sponsorshipFundació Catalana de Trasplantamentes_ES
dc.description.sponsorshipDepartament de Salut, Generalitat de Catalunya CES09/020es_ES
dc.description.sponsorshipPrograma Operacional Temático Factores de Competitividadees_ES
dc.description.sponsorshipSpanish National Plan for Scientific and Technical Research and Innovation PID2020-120157RB-I00, SAF2016-78722-Res_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleImmune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertilityes_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1038/s42003-022-04192-0
dc.type.hasVersionVoRes_ES


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