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dc.contributor.authorDimou, Niki
dc.contributor.authorSánchez Pérez, María José
dc.identifier.citationNiki Dimou... [et al.]. Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses. Cancer Epidemiol Biomarkers Prev 1 September 2022; 31 (9): 1839–1848. []es_ES
dc.description.abstractBackground: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. Methods: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In twosampleMR analyses, genetic variants robustly associated with lifetime amount of smoking (n ¼ 126 variants) and ever having smoked regularly (n ¼ 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. Results: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91–1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. Conclusions: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. Impact: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.es_ES
dc.description.sponsorshipWorld Health Organizationes_ES
dc.description.sponsorshipDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College Londones_ES
dc.description.sponsorshipNIHR Imperial Biomedical Research Centre (BRC)es_ES
dc.description.sponsorshipDanish Cancer Societyes_ES
dc.description.sponsorshipLigue Contre le Cancer (France) Institut Gustave Roussy (France) MutuelleGenerale de l'Education Nationale (France)es_ES
dc.description.sponsorshipInstitut National de la Sante et de la Recherche Medicale (Inserm)es_ES
dc.description.sponsorshipDeutsche Krebshilfe German Cancer Research Center (DKFZ) (Germany) German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany) Federal Ministry of Education & Research (BMBF)es_ES
dc.description.sponsorshipFondazione AIRC per la ricerca sul cancro Compagnia di San Paolo Consiglio Nazionale delle Ricerche (CNR)es_ES
dc.description.sponsorshipNetherlands Government Netherlands Governmentes_ES
dc.description.sponsorshipWorld Cancer Research Fund International (WCRF)es_ES
dc.description.sponsorshipNetherlands Governmentes_ES
dc.description.sponsorshipHealth Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII) (Spain)es_ES
dc.description.sponsorshipJunta de Andaluciaes_ES
dc.description.sponsorshipPrincipality of Asturias Regional Government of Basque Country (Spain) Regional Government of Murcia (Spain) Regional Government of Navarra (Spain) Catalan Institute of Oncology - ICO (Spain)es_ES
dc.description.sponsorshipSwedish Cancer Society Swedish Research Council County Council of Skane (Sweden) County Council of Vasterbotten (Sweden)es_ES
dc.description.sponsorshipCancer Research UK 14136 C8221/A29017es_ES
dc.description.sponsorshipUK Research & Innovation (UKRI)es_ES
dc.description.sponsorshipMedical Research Council UK (MRC) 1000143 MR/M012190/1 MR/N003284/1 MC-UU_12015/1 MC_UU_00006/ 1es_ES
dc.description.sponsorshipCancer Research UK C864/A14136 C18281/A29019es_ES
dc.description.sponsorshipCancer Research UK C864/A14136 C18281/A29019es_ES
dc.publisherAmerican Association for Cancer Researches_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.titleCigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyseses_ES

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