Production Technologies, Regulatory Parameters, and Quality Control of Vaccine Vectors for Veterinary Use
Metadata
Show full item recordEditorial
MDPI
Materia
Vaccines Veterinary application Bacteria Toxins Antigenic residues
Date
2022-10-21Referencia bibliográfica
Barbosa, R.d.M... [et al.]. Production Technologies, Regulatory Parameters, and Quality Control of Vaccine Vectors for Veterinary Use. Technologies 2022, 10, 109. [https://doi.org/10.3390/technologies10050109]
Sponsorship
Portuguese Foundation for Science and Technology UIDB/04033/2020; FEDER under the Partnership Agreement PT2020; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES); Fundacao de Amparo a Pesquisa do Estado do Sergipe (FAPITEC) 88887.159533/2017-00; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 301964/2019-0 Chamada 06/2019 01/2019; Junta de Andalucia PT18 RT 3786Abstract
This paper presents a comprehensive review of the main types of vaccines approaching
production technology, regulatory parameters, and the quality control of vaccines. Bioinformatic tools
and computational strategies have been used in the research and development of new pharmaceutical
products, reducing the time between supposed pharmaceutical product candidates (R&D steps)
and final products (to be marketed). In fact, in the reverse vaccinology field, in silico studies can
be very useful in identifying possible vaccine targets from databases. In addition, in some cases
(subunit or RNA/ DNA vaccines), the in silico approach permits: (I) the evaluation of protein
immunogenicity through the prediction of epitopes, (II) the potential adverse effects of antigens
through the projection of similarity to host proteins, (III) toxicity and (IV) allergenicity, contributing
to obtaining safe, effective, stable, and economical vaccines for existing and emerging infectious
pathogens. Additionally, the rapid growth of emerging infectious diseases in recent years should be
considered a driving force for developing and implementing new vaccines and reassessing vaccine
schedules in companion animals, food animals, and wildlife disease control. Comprehensive and
well-planned vaccination schedules are effective strategies to prevent and treat infectious diseases.