Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine
Metadatos
Afficher la notice complèteAuteur
Banegas, Inmaculada; Vives Montero, Francisco; Durán Ogalla, Raquel; Luna Del Castillo, Juan De Dios; Domínguez Vías, GermanEditorial
MDPI
Materia
Dopamine Limbic system Medial prefrontal cortex Hippocampus Amygdala Brain asymmetry Hypertension Asymmetrical neurovisceral integration Proteinases Aminopeptidases Renin-angiotensin system
Date
2022-10-01Referencia bibliográfica
Banegas, I... [et al.]. Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine. Biomedicines 2022, 10, 2457. [https://doi.org/10.3390/biomedicines10102457]
Patrocinador
Junta de Andalucia PAI CVI-221 CTS 438Résumé
Brain dopamine, in relation to the limbic system, is involved in cognition and emotion.
These functions are asymmetrically processed. Hypertension not only alters such functions but
also their asymmetric brain pattern as well as their bilateral pattern of neurovisceral integration.
The central and peripheral renin-angiotensin systems, particularly the aminopeptidases involved
in its enzymatic cascade, play an important role in blood pressure control. In the present study, we
report how these aminopeptidases from left and right cortico-limbic locations, plasma and systolic
blood pressure interact among them in spontaneously hypertensive rats (SHR) unilaterally depleted
of dopamine. The study comprises left and right sham and left and right lesioned (dopaminedepleted)
rats as research groups. Results revealed important differences in the bilateral behavior
comparing sham left versus sham right, lesioned left versus lesioned right, and sham versus lesioned
animals. Results also suggest an important role for the asymmetrical functioning of the amygdala
in cardiovascular control and an asymmetrical behavior in the interaction between the medial
prefrontal cortex, hippocampus and amygdala with plasma, depending on the left or right depletion
of dopamine. Compared with previous results of a similar study inWistar-Kyoto (WKY) normotensive
rats, the asymmetrical behaviors differ significantly between both WKY and SHR strains.