DNA/RNA sequencing using germanene nanoribbons via two dimensional molecular electronic spectroscopy: an ab initio study
Metadatos
Mostrar el registro completo del ítemEditorial
Royal Society of Chemistry
Fecha
2022-03-03Referencia bibliográfica
Nanoscale, 2022, 14, 5147. DOI: [10.1039/d1nr07336b]
Patrocinador
H2020 Marie Sklodowska-Curie Actions 841673; European Commission MAT2017-88258-R; Programa Operativo FEDER of Andalucia 2014-2020 B-FQM-272-UGR20 AEI MAT2017-88258-RResumen
Developing fast, reliable, and cost effective, yet practical DNA/RNA sequencing methods and devices is a
must. In this regard, motivated by the recently introduced two-dimensional electronic molecular spectroscopy
(2DMES) technique for molecular recognition, and the compatibility of 2D layers of group IV
elements with the current technology of manufacturing electronic devices, we investigate the capability
of germanene nanoribbons (GeNRs) as a feasible, accurate, and ultra-fast sequencing device under the
application of 2DMES. We show that by employing 2DMES, not only can GeNRs unambiguously distinguish
different nucleobases to sequence DNA/RNA, they are also capable of recognizing methylated
nucleobases that could be related to cancerous cell growth. Our calculations indicate that, compared to
frequently used graphene layers, germanene provides more distinct adsorption energies for different
nucleobases which implies its better ability to recognize various molecules unambiguously. By calculating
the conductance sensitivity of the system for experimental purposes, we also show that the introduced
sequencing device possesses a high sensitivity and selectivity characteristic. Thus, our proposed system
would be a promising device for next-generation DNA sequencing technologies and would be realizable
using the current protocols of fabricating electronic devices.