Associations of the Lipidome with Ageing, Cognitive Decline and Exercise Behaviours
Metadatos
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MDPI
Materia
Lipidomics Exercise Ageing Cognition Metabolism Metabolic phenotyping Liquid chromatography–mass spectrometry (LC–MS) Nuclear magnetic resonance spectroscopy (NMR)
Fecha
2022-08-31Referencia bibliográfica
Kadyrov, M... [et al.]. Associations of the Lipidome with Ageing, Cognitive Decline and Exercise Behaviours. Metabolites 2022, 12, 822. [https://doi.org/10.3390/metabo12090822]
Patrocinador
Australian Research Council FL200100220Resumen
One of the most recognisable features of ageing is a decline in brain health and cognitive
dysfunction, which is associated with perturbations to regular lipid homeostasis. Although ageing
is the largest risk factor for several neurodegenerative diseases such as dementia, a loss in cognitive
function is commonly observed in adults over the age of 65. Despite the prevalence of normal agerelated
cognitive decline, there is a lack of effective methods to improve the health of the ageing
brain. In light of this, exercise has shown promise for positively influencing neurocognitive health
and associated lipid profiles. This review summarises age-related changes in several lipid classes that
are found in the brain, including fatty acyls, glycerolipids, phospholipids, sphingolipids and sterols,
and explores the consequences of age-associated pathological cognitive decline on these lipid classes.
Evidence of the positive effects of exercise on the affected lipid profiles are also discussed to highlight
the potential for exercise to be used therapeutically to mitigate age-related changes to lipid metabolism
and prevent cognitive decline in later life.