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dc.contributor.authorMartínez Téllez, Borja Manuel 
dc.contributor.authorSánchez Delgado, Guillermo 
dc.contributor.authorAcosta, Francisco M.
dc.contributor.authorAlcántara Alcántara, Juan Manuel 
dc.contributor.authorAmaro Gahete, Francisco José 
dc.contributor.authorMartínez Ávila, Wendy D.
dc.contributor.authorMerchán Ramírez, Elisa 
dc.contributor.authorMuñoz Hernández, María Victoria
dc.contributor.authorOsuna Prieto, Francisco Javier 
dc.contributor.authorJurado Fasoli, Lucas 
dc.contributor.authorXu, Huiwen 
dc.contributor.authorOrtiz Álvarez, Lourdes 
dc.contributor.authorArias Téllez, María José 
dc.contributor.authorMéndez Gutiérrez, Andrea
dc.contributor.authorOrtega Porcel, Francisco Bartolomé 
dc.contributor.authorAguilera García, Concepción María 
dc.contributor.authorLlamas Elvira, José Manuel 
dc.contributor.authorGil Hernández, Ángel 
dc.contributor.authorRuiz Ruiz, Jonatan 
dc.date.accessioned2022-10-03T07:46:39Z
dc.date.available2022-10-03T07:46:39Z
dc.date.issued2022-09-12
dc.identifier.citationMartinez-Tellez, B... [et al.]. No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial. Nat Commun 13, 5259 (2022). [https://doi.org/10.1038/s41467-022-32502-x]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/77123
dc.description.abstractExercise modulates both brown adipose tissue (BAT)metabolismand white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n=31, and VIG-EX; n=31).We observed no changes in BAT volume (Δ Control: −22.2 ± 52.6ml; Δ MOD-EX: −15.5 ± 62.1ml, Δ VIG-EX: −6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: −2.6 ± 3.1ml; Δ MOD-EX: −1.2 ± 4.8, Δ VIG-EX: −2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults.es_ES
dc.description.sponsorshipSpanish Government PI13/01393es_ES
dc.description.sponsorshipRetos de la Sociedad DEP2016-79512-R PTA-12264Ies_ES
dc.description.sponsorshipEuropean Commissiones_ES
dc.description.sponsorshipSpanish Government FPU13/04365 FPU14/04172 FPU15/04059 FPU16/03653 FPU19/01609es_ES
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnologia (CONACyT) 440575es_ES
dc.description.sponsorshipFundacion Iberoamericana de Nutricion (FINUT)es_ES
dc.description.sponsorshipRedes Tematicas de Investigacion Cooperativa RETIC Red SAMID RD16/0022es_ES
dc.description.sponsorshipAstraZenecaes_ES
dc.description.sponsorshipUniversity of Granada Plan Propio de Investigacion 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES)es_ES
dc.description.sponsorshipPlan Propio de Investigacion 2018 -Programa Contratos-Puentees_ES
dc.description.sponsorshipPrograma Perfecionamiento de Doctoreses_ES
dc.description.sponsorshipJunta de Andalucia Consejeria de Conocimiento, Investigacion y Universidades (ERDF) SOMM17/6107/UGRes_ES
dc.description.sponsorshipJunta de Andalucia P18-RT-4455es_ES
dc.description.sponsorshipFundacion Alfonso Martin Escuderoes_ES
dc.description.sponsorshipMaria Zambrano fellowship by the Ministerio de Universidades y la Union Europea-NextGenerationEU RR_C_2021_04es_ES
dc.description.sponsorshipNovo Nordisk Foundationes_ES
dc.description.sponsorshipNovocure Limited NNF18OC0032394es_ES
dc.language.isoenges_ES
dc.publisherNaturees_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleNo evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled triales_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1038/s41467-022-32502-x
dc.type.hasVersionVoRes_ES


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