Vitamin D Status in Critically Ill Patients with SIRS and Its Relationship with Circulating Zn and Related Parameters during ICU Stay
Metadatos
Mostrar el registro completo del ítemAutor
Herrera Quintana, Lourdes María; Vázquez Lorente, Héctor; Gamarra Morales, Yenifer; Martín López, Javier Ignacio; Planells Del Pozo, Elena MaríaEditorial
MDPI
Materia
Vitamin D Zinc Critically ill patient Intensive Care Unit Systemic Inflammatory Response Syndrome
Fecha
2022-08-30Referencia bibliográfica
Herrera-Quintana, L... [et al.]. Vitamin D Status in Critically Ill Patients with SIRS and Its Relationship with Circulating Zn and Related Parameters during ICU Stay. Nutrients 2022, 14, 3580. [https://doi.org/10.3390/nu14173580]
Patrocinador
FIS projects of the Carlos III Health Institute PI10/1993; Spanish Government A-CTS-708-UGR20 FPU18/03702 FPU18/03655Resumen
Critically ill patients are exposed to different stressors which may generate Systemic
Inflammatory Response Syndrome (SIRS). This situation hinders the assessment of micronutrients
status, such as vitamin D or Zinc (Zn), potentially affecting patients’ treatment and recovery. The
aim of the present study was to assess the evolution of circulating 25–Hydroxyvitamin D (25–OH–D)
levels after seven days of Intensive Care Unit (ICU) stay and the influence on changes in plasma and
erythrocyte Zn levels, as well as other parameters related to phosphorus–calcium metabolism. A
prospective analytical study was conducted on 65 critically ill patients (42% women) aged 31–77 years
with SIRS. Total 25–OH–D levels were measured in plasma samples by liquid chromatographytandem
mass spectrometry, and Zn content was analyzed by flame atomic absorption spectrometry.
Both 25–OH–D and 25–OH–D3 levels were directly associated with erythrocyte Zn concentration at
follow-up (p = 0.046 and p = 0.011, respectively). A relationship between erythrocyte and plasma Zn
was also found at this follow-up point. No such clear associations were found when considering 25–
OH–D2. Different disturbances in levels of phosphorus–calcium metabolism parameters were found,
suggesting a relationship between the changes of 25–OH–D3 levels and parathormone (p = 0.019) and
phosphorus (p = 0.005). The findings of the present study suggest an interaction between vitamin D
and Zn, in which the correct status of these micronutrients could be a potentially modifiable factor
and a beneficial approach in the recovery of critically ill patients.