Association of preconception mixtures of phenol and phthalate metabolites with birthweight among subfertile couples
Metadatos
Mostrar el registro completo del ítemEditorial
Lippincot Williams & Wilkins
Materia
Phthalate Phenol Preconception Paternal Birthweight Singleton
Fecha
2022-08-31Referencia bibliográfica
Zhang, Yua... [et al.]. Association of preconception mixtures of phenol and phthalate metabolites with birthweight among subfertile couples. Environmental Epidemiology: October 2022 - Volume 6 - Issue 5 - p e222 doi: [10.1097/EE9.0000000000000222]
Patrocinador
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Environmental Health Sciences (NIEHS) R01ES031657 R01ES028800 ES009718 ES000002Resumen
Background: Although parental preconception exposure to some phenols and phthalates have been associated with reduced
birthweight, few studies have examined these chemicals as complex mixtures.
Methods: We included 384 mothers and 211 fathers (203 couples) who gave birth to 384 singletons from a prospective cohort of
couples seeking fertility evaluation. Urinary concentrations of bisphenol A (BPA), parabens, and 11 phthalate metabolites including
those of di(2-ethylhexyl) phthalate (DEHP) were examined. Birthweight was abstracted from delivery records. We used principal
component analysis and Bayesian Kernel Machine Regression (BKMR) to examine maternal and paternal preconception mixtures in
relation to singleton birthweight. We also fit couple-based BKMR with hierarchical variable selection to assess couples’ joint mixtures
in relation to birthweight.
Results: PC scores of maternal and paternal preconception low molecular weight phthalates factor, and paternal preconception
DEHP-BPA factor were associated with reduced birthweight. In BKMR models, we found that maternal preconception monoethyl
phthalate and BPA concentrations, and paternal preconception mono-n-butyl phthalate concentrations were inversely associated
with birthweight when the remaining mixture components were held at their median concentrations. In couple-based BKMR models,
paternal preconception biomarkers contributed more to couples’ joint effect on birthweight compared with maternal preconception
biomarkers. A decreasing trend of birthweight was observed across quantiles of maternal, paternal, and couples’ total preconception
mixture concentrations, respectively.
Conclusions: Results from this preconception cohort of subfertile couples suggest a complex interplay between paternal and
maternal preconception exposure to mixtures of nonpersistent chemicals, with both parental windows of exposure jointly contributing
to reduced birthweight.